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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제9권 제1호
- 발행연도
- 2016.1
- 수록면
- 75 - 79 (5page)
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Objectives. This study aimed to evaluate the significance of metastatic lymph node ratio (the ratio between the metastatic lymph node and the harvested lymph nodes; MLNR) in the central neck for the prediction of locoregional recurrence in patients with papillary thyroid microcarcinoma.
Methods. After reviewing medical records of papillary thyroid microcarcinoma patients who received total thyroidectomy with central neck node dissection, 573 consecutive adult patients were enrolled in this study, with a follow-up period of more than 36 months. Regarding the risk of recurrence, multivariate analyses were performed with the following variables; sex, age, multiplicity of the primary tumor, presence of pathological extrathyroidal extension, the level of postoperative stimulated serum thyroglobulin, the number of harvested lymph nodes, the number of lymph node metastasis and MLNR.
Results. The MLNR showed a predictive significance for the locoregional recurrence (P<0.05). Most recurrences were occurred in the lateral neck (n=12, 80%) with a median interval of 20 months. The lowest cutoff value of the MLNR for a meaningful separation of disease recurrence was 0.44 (hazard ratio, 8.86; 95% confidence interval, 1.49 to 52.58; P=0.001).
Conclusion. When the MLNR is higher than 0.44, there is an increased risk of locoregional recurrence mostly in the lateral neck. Therefore, MLNR of the central neck in a permanent or frozen biopsy may be helpful in decision making in the extent of thyroidectomy and/or the need for contralateral central neck lymph nodes dissection.
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참고문헌 (25)
참고문헌 신청
Ito Y. / 2006 / Clinical significance of lymph node metastasis of thyroid papillary carcinoma located in one lobe / World J Surg 30(10):1821~1828
Lundgren CI. / 2006 / Clinically significant prognostic factors for differentiated thyroid carcinoma : a population-based, nested case-control study / Cancer 106(3):524~531
Podnos YD. / 2005 / The implication of lymph node metastasis on survival in patients with well-differentiated thyroid cancer / Am Surg 71(9):731~734
Edge SB. / 2010 / The American Joint Committee on Cancer : the 7th edition of the AJCC cancer staging manual and the future of TNM / Ann Surg Oncol 17(6):1471~1474
Wada N. / 2003 / Lymph node metastasis from 259 papillary thyroid microcarcinomas : frequency, pattern of occurrence and recurrence, and optimal strategy for neck dissection / Ann Surg 237(3):399~407
Lundgren CI. / 2006 / Clinically significant prognostic factors for differentiated thyroid carcinoma : a population-based, nested case-control study / Cancer 106(3):524~531
Podnos YD. / 2005 / The implication of lymph node metastasis on survival in patients with well-differentiated thyroid cancer / Am Surg 71(9):731~734
Edge SB. / 2010 / The American Joint Committee on Cancer : the 7th edition of the AJCC cancer staging manual and the future of TNM / Ann Surg Oncol 17(6):1471~1474
Wada N. / 2003 / Lymph node metastasis from 259 papillary thyroid microcarcinomas : frequency, pattern of occurrence and recurrence, and optimal strategy for neck dissection / Ann Surg 237(3):399~407
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