일측성 성대마비 환자에서 Cross-Linked Hyaluronic Acid Gel을이용한 성대주입술의 효과 및 안전성

오재원; 손영익; 이현종; 이승원; 김관민

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자료유형: 학술저널

저자정보: 오재원 손영익 이현종 이승원 김관민

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제48권 제10호

발행연도: 2005.1

수록면: 1,248 - 1,253 (6page)

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연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

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Background and Objectives：Hyaluronic acid (HA) is a natural polysaccharide, which resides in the extracellular space of all mammalian connective tissue and creates viscoelasticity, hydrating, lubricating and stabilizing matrix. The authors aimed to determine the clinical efficacy and safety of using HA derivative as an injection material to correct the glottal insufficiency of patients with unilateral vocal cold palsy (VCP). Subjects and Method：Twenty-eight consecutive patients with recent unilateral VCP received percutaneous HA derivative (Rofilan) injections under local anesthesia. Acoustic, aerodynamic and stroboscopic analyses were prospectively provided for the 14 subjects prior to the injection, and 1 week and 3 months after the injection. Perceptual GRBAS grading by speech language pathologists and subjective ratings of the hoarseness and aspiration by the patients were also obtained. Results：Acoustic (jitter and shimmer) and aerodynamic (maximal phonation time) parameters were significantly improved after the injection (p<0.05). Perceptual grading and subjective scaling also showed significant improvement. Those beneficial effects could be maintained for longer than 3 months but with a tendency of losing their effects with time. Early or delayed significant side effects were not observed. Conclusion：Vocal fold injection with HA derivative is a convenient, safe and useful method of correcting glottal insufficiency for more than 3 months. The patients with recently developed unilateral VCP with unknown possibility of recovery would be suitable candidates for HA injection. Further long-term follow-up studieswill answer the durability of the HA injection effect.

#성대마비·하이알 유로네이트·성대·애성. #Vocal cord paralysis·Hyaluronate·Vocal cords·Hoarseness.

참고문헌 (20)

참고문헌 신청

/ 1997 / Theintermediate layer:A morphologic study of the elastin and hyaluronicacid constituents of normal human vocal folds 11 : 59 ~ 66

/ 1998 / Dextranomeres in hyaluronan A promising substance in treating vocal cord insufficiency : 393 ~ 7

/ 1998 / Injectablehyaluronic acid gel for soft tissue augmentation : 1317 ~ 25

/ 1999 / A new injectable remedy for treatment of vocal fold insufficiency--an animal study : 107 ~ 11

/ 1999 / Vocal fold proteoglycansand their influence on biomechanics 109 : 845 ~ 54

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