폐렴연쇄구균을 이용한 생쥐에서의 만성 비부비동염 실험모델

김동은; 남성일; 김상표; 박연호; 류남희; 안병훈; 송인혁; 남영진

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자료유형: 학술저널

저자정보: 김동은 남성일 김상표 박연호 류남희 안병훈 송인혁 남영진

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제49권 제1호

발행연도: 2006.1

수록면: 52 - 59 (8page)

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Background and Objectives：A mouse has a great potential to be used in studying genetics and inflammatory process of the rhinosinusitis. The aim of this study was to observe effects of experimentally induced chronic rhinosinusitis on histopathology of the sinonasal mucosa in a mouse and to develop a chronic form of rhinosinusitis. Materials and Method：Thirty five, six-week old male C57BL/6 mice were used as follows：7 normal controls without intervention, 7 Sham operated controls, 7 animals with ostial obstruction alone using Merocel, 7 animals implanted with Merocel plus 106 colony forming unit (CFU)/mL of Streptococcus pneumoniae and 7 animals implanted with Merocel plus 108 CFU/mL of S. pneumoniae. Six weeks after intervention, the animals were sacrificed and serially sectioned at 1 mm intervals and stained with Hematoxylin and Eosin. Results：Increased epithelial thickness, goblet cell hyperplasia, epithelial disarray and inflammatory infiltration were observed in the experimental sinuses packed with Merocel alone or Merocel with bacterial inoculation, especially at the nasal septal area. However, there were no significant differences between the Merocel only inserted group and Merocel and bacteria inoculated group. Conclusion：Maxillary sinus ostial obstruction or ostial obstruction with S. pneumoniae inoculation induced chronic rhinosinusitis in C57BL/6 mice as indicated by the histologic change. This study could be used as a model of chronic rhinosinusitis for further study. (Korean J Otolaryngol 2006;49:52-9)

#부비동염·생쥐·폐렴연쇄구균. #Sinusitis·Mice·Streptococcus pneumoniae.

참고문헌 (19)

참고문헌 신청

/ / Effects of operative windowon normal sinuses : 379 ~ 92

/ 1985 / Blood flow in the rabbit sinus mucosaduring experimentally induced chronic sinusitis.Measurement with adiffusible and with a non-diffusible tracer 99 : 630 ~ 6

/ 1991 / A scanning electron microscopicstudy on density of epithelial cells in normal maxillary sinus mucosaof rabbit 34 : 1195 ~ 211

/ 1994 / Chronic sinusitis:Clinical and pathophysiological aspects 515 : 45 ~ 8

/ 1995 / Mucociliary activityand histopathology of sinus mucosa in experimental maxillary sinusitis:A comparison of systemic administration of antibiotic and antibioticdeliv

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