결핵성 경부 림프절염의 항결핵제 치료기간에 관한 연구:6개월과 12개월 요법의 무작위 임상대조연구

임기정; 권윤환; 백승국; 우정수; 권순영; 정광윤; 박대원; 손장욱; 김민자; 천병철

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자료유형: 학술저널

저자정보: 임기정 권윤환 백승국 우정수 권순영 정광윤 박대원 손장욱 김민자 천병철

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제47권 제3호

발행연도: 2004.1

수록면: 258 - 262 (5page)

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Background and Objectives：Tuberculous cervical lymphadenitis is one of the most common extrapulmonary manifestations of tuberculosis. Foreign guidelines recommend a six-month short course chemotherapy for tuberculous peripheral lymphadenitis as an initial standard regimen. However, there have been some debates about the duration of chemotherapy in South Korea. The aim of this study is to determine the reasonable duration of chemotherapy for tuberculous cervical lymphadenitis in a randomized controlled study. Subjects and Method：We analyzed clinical outcome of 80 patients with tuberculous cervical lymphadenitis treated at Korea University Medical Center from April 1998 to November 2001. All patients were randomized in two groups by treatment regimens. All patients were given antituberculous chemotherapy for 6 or 12 months, starting with isoniazid (H), rifampicin (R), ethambutol (E) and pyrazinamide (P) for 2 months, then continuing with isoniazid, rifampicin and ethambutol for the remaining 4 months or 10 months, respectively. Results：Forty-seven patients were given a 12-month regimen (2 HERZ/10 HRE), and 43 patients (91.5%) were cured. Thirty-three patients were given a 6-month regimen (2 HERZ/ 4 HRE), and 20 patients (60.6%) were cured. The cure rate of the 12-month regimen appeared significantly higher than that of the 6-month. In both groups, no recurrence was found during the follow up period up to 12 months. Conclusion：The 12-month regimen could be recommended as a reasonable chemotherapy regimen for tuberculous cervical lymphadenitis in South Korea. Single lymph node excisional biopsy is an important diagnostic method. but, it has no additional benefits of treatment.

#결핵·경부 림프절염·항결핵제·치료기간. #Tuberculosis· Lymphadenitis· Chemotherapy· Clinical protocols.

참고문헌 (13)

참고문헌 신청

/ 1974 / Tuberculous cervical lymphadenitis. 99 : 327 ~ 329

/ 1992 / CT manifestation of cervicaltuberculous lymphadenitis 28 : 182 ~ 187

/ 1993 / Sixmonths versus nine months chemotherapy for tuberculosis of lymphnodes:Final results 87 : 621 ~ 623

/ 1994 / Treatment of tuberculosis and tuberculosis infection in adults andchildren, American Thoracic Society and the Centers for Disease Controland Prevention. 149 : 1359 ~

/ 1997 / Clinicalinvestigation of cervical tuberculous lymphadenitis 44 : 1225 ~ 1232

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