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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 646 - 650 (5page)
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초록· 키워드
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Background and Objectives：Salicylates are well-known for producing reversible hearing loss and tinnitus. However, the site and mechanism of salicylate ototoxicity remain unresolved. Recent experiments sugest that reversible biochemical and/ or metabolic changes in the cochlea seem to play an important role in salicylate ototoxicity. The purpose of this study was to Materials and Method：ABRs and DPOAEs were observed after intraperitoneal injection of 500 mg/kg of sodium salicylate on 24 ears of guinea pigs. Results：Salicylate pro-duced a significant increase in the ABR threshold. Maximum changes were obtained in 4 hours, and recovered to the base-line in 24 hours after salicylate administration. The pattern of hearing loss shown by latency-intensity function was compatible with the cochlear type of hearing loss. The echo amplitude on DPOAEs at f2＝2, 4, 6, 8 hours, and returned to the baseline in 24 hours after salicylate administration. The time course of the change of DP-OAEs was parallel with that of ABRs. Conclusion：These results reflect that the cochlear outer hair cells may be the main site of lesion in salicylate ototoxicity. (Korean J Otolaryngol 2002;45:646-50)
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