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논문 기본 정보

자료유형
학술저널
저자정보
Dolen, Utku Can (Department of Plastic Surgery, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital) Sungur, Nezih (Plastic Surgery Clinic, Ankara Training and Research Hospital) Koca, Gokhan (Department of Nuclear Medicine, Ankara Training and Research Hospital) Ertunc, Onur (Department of Pathology, Medical School of Gazi University) Bosi, Ayse Tulay Bagci (Department of Public Health, Medical School of Hacettepe University) Kocer, Ugur (Plastic Surgery Clinic, Ankara Training and Research Hospital) Korkmaz, Meliha (Department of Nuclear Medicine, Ankara Training and Research Hospital)
저널정보
대한성형외과학회 Archives of plastic surgery : APS Archives of plastic surgery : APS 제42권 제6호
발행연도
2015.1
수록면
695 - 703 (9page)

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Background It is still difficult to prevent partial or full-thickness flap necrosis. In this study, the effects of a cream containing menthol and methyl salicylate on the viability of random-pattern skin flaps were studied. Methods Forty female Sprague-Dawley rats were divided into two equal groups. Caudally based dorsal random-pattern skin flaps were elevated, including the panniculus carnosus. In the study group, 1.5 mL of a cream containing menthol and methyl salicylate was applied to the skin of the flap, and saline solution (0.9%) was used in the control group. Upon completion of the experiment, flap necrosis was analyzed with imaging software and radionuclide scintigraphy. Histopathological measurements were made of the percentage of viable flaps, the number of vessels, and the width of the panniculus carnosus muscle. Results According to the photographic analysis, the mean viable flap surface area in the study group was larger than that in the control group (P=0.004). According to the scintigrams, no change in radioactivity uptake was seen in the study group (P>0.05). However, a significant decrease was observed in the control group (P=0.006). No statistically significant differences were observed between the groups in terms of the percentage of viable flaps, the number of vessels, or the width of the panniculus carnosus muscle (P>0.05). Conclusions Based on these results, it is certain that the cream did not reduce the viability of the flaps. Due to its vasodilatory effect, it can be used as a component of the dressing in reconstructive operations where skin perfusion is compromised.

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