후두 편평세포암종에서 Platelet-Derived Endothelial Cell Growth Factor (PD-ECGF), Basic Fibroblast Growth Factor(bFGF), Vascular Endothelial Growth Factor(VEGF)의 발현과 임상병기와의 관계

김현수; 이민호; 허경욱; 박세광; 엄재욱

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자료유형: 학술저널

저자정보: 김현수 이민호 허경욱 박세광 엄재욱

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제45권 제5호

발행연도: 2002.1

수록면: 488 - 494 (7page)

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Background and Objectives：wounds and fractures. By contrast, uncontrolled angiogenesis can often be pathological. Vascular remodelling could there-fore play an important role in the growth proces of solid tumors. The aim of this study was to detect the expresion of platelet-derived endothelial cell growth factor (PD-ECGF), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF), and investigate the correlation between these factors. Also, we studied the relationships between the larynx. Materials and Method：The authors examined the expression of three angiogenic factors in specimens of laryngeal squamous cell carcinoma (n＝17). The mRNA expressions of angiogenic factors were detected by the semi-quantitative re-verse transcription-polymerase chain reaction (RT-PCR). Statistics were analysed using the Fisher's exact test, the Wilcoxon signed rank test, and the Spearman correlation coefficiency. Results：PD-ECGF and bFGF were significantly higher in the involvement. The expression of more than one factor was significantly related with stages III and IV cancer. PD-ECGF and VEGF were related with each other. Conclusion：The authors sugest that angiogenic factors, especially, PD-ECGF and bFGF, may be used as prognostic factors for the squamous cell carcinoma of larynx. (Korean J Otolaryngol 2002;45:488-94)

#편평세포암·후두·신생혈관생성인자. #Carcinoma·Squamous cell·Larynx·Angiogenesis factor.

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