만성기침을 동반한 만성 비부비동염 환자에서 비강분비물과 기관폐포세척액의 세포병리학적 비교

노환중; 이일우; 왕수건; 김철민; 이민기; 박순규

추천

검색

자료유형: 학술저널

저자정보: 노환중 이일우 왕수건 김철민 이민기 박순규

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제46권 제1호

발행연도: 2003.1

수록면: 42 - 47 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background and Objectives：Postnasal drip is one of the most comon symptoms of chronic rhinosinusitis (CRS), and is the main cause of chronic cough. To evaluate the effect of upper airway inflammation defined as CRS on lower bronchial airway, we compared the cytology of nasal secretion (NS) and bronchoalveolar lavage fluid (BALF) of normal controls and patients with chronic rhinosinusitis acompanying with and without chronic cough normal controls. Materials and Method：Ten patients . NS collected using Juhns tymanic tap and BALF collected through fiberoptic bronchoscopy were diluted with dithiothreitol and PBS. These samples were centrifused and then cytospin slide was prepared. The cytology of the slides were evaluated under light microscope after Wright stain. To examine neutrophil activity, nitroblue tetrazolium dye (NBT) test was performd. Statis-tical analysis was performed using Mann-Whitney Rank Sum W test. Results：In NS, there were no significant diferences in the cel populations among coughing, noncoughing, and the normal control group. NBT positivity of coughing (34.2%) and noncoughing ( ) groups showed significantly higher than those of controls (8.6%). In BALF of coughing group, the popu-lation of macrophages (78.0%) was significantly lower than noncoughing (86.6%) and control (92.8%) groups, and population of lymphocytes (20.8%) was significantly higher than noncoughing (12.6%) and the control (6.4%) groups. In BALF of Conclusion：These results suggest that CRS enhances increased local imune responses and decreased phagocytic activity of the lower airway. And chronic cough in patients with CRS is thought to be dependent on individual tolerance to cough provocation, not on aspiration of postnasal drip of discharge. (Korean J Otolaryngol 2003 ;46 :42-7)

#기침·부비동염·기관폐포세척. #Cough· Sinusitis· Bronchoalveolar lavage.

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!