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Chronic Refractory Cough
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만성 난치성 기침

논문 기본 정보

Type
Academic journal
Author
Journal
The Korean Association Of Internal Medicine 대한내과학회지 대한내과학회지 제91권 제1호 KCI Candidated Journals
Published
2016.1
Pages
18 - 27 (10page)

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Chronic Refractory Cough
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Abstract· Keywords

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Chronic refractory cough is defined as a cough that persists despite guideline based treatment. It is seen in 20-46% of patients presenting to specialist cough clinics and it has a substantial impact on quality of life and healthcare utilization. Several terms have been used to describe this condition, including the recently introduced term cough hypersensitivity syndrome. Key symptoms include a dry irritated cough localized around the laryngeal region. Symptoms are not restricted to cough and can include globus, dyspnea, and dysphonia. Chronic refractory cough has factors in common with laryngeal hypersensitivity syndromes and chronic pain syndromes, and these similarities help to shed light on the pathophysiology of the condition. Its pathophysiology includes cough reflex sensitivity, central sensitization, peripheral sensitization, and paradoxical vocal fold movement. Chronic refractory cough often occurs after a viral infection. The diagnosis is made once the main disease that causes chronic cough have been excluded (or treated) and cough remains refractory to medical treatment. Treatments include speech pathology interventions using techniques adapted from the treatment of hyperfunctional voice disorders, as well as the use of centrally acting neuromodulators such as gabapentin and pregabalin. Potential new treatments in development also show promise.
#기침 #Cough

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References (51)

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Chung KF / 2008 / Prevalence, pathogenesis, and causes of chronic cough / Lancet 371:1364~1374 google schola Song WJ / 2015 / The global epidemiology of chronic cough in adults : a systematic review and meta-analysis / Eur Respir J 45:1479~1481 google schola Song WJ / 2013 / Cough in the elderly population : relationships with multiple comorbidity / PLoS One 8:78081 google schola 이진국 / 2016 / The Korean Cough Guideline: Recommendation and Summary Statement / Tuberculosis and Respiratory Diseases 79(1):14~21 google schola Irwin RS / 2014 / Overview of the management of cough : CHEST guideline and expert panel report / Chest 146:885~889 google schola

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