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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 112 - 117 (6page)
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Altered mRNA expression of two metallothionein isoforms (MT-IA and MT-IB) in response to acute heavy metal exposure was examined in mud loach, Misgurnus mizolepis, fry using a real-time RT-PCR assay. Sublethal exposure (1 or 5 μM) to Cd, Cr, Fe, Mn, Ni, and Zn resulted in highly variable transcriptional responses of the two MT isoforms to the heavy metal ions, including upregulation, a steady state, and downregulation. Overall, the most potent inducer of both MT isoforms was Cd (up to 6-fold). Another exposure experiment using a series of doses of Cu revealed that the stimulation patterns of the two MT isoforms differed: MT-IA transcription was soon saturated at higher concentrations (about 2-fold at 1-4 μM of Cu), whereas the activation of MT-IB was more dependent on the treatment dose (increased up to 5-fold at 3 μM). The isoform-specific allotment of constitutive and inducible functions was not as clear in fry as in adult tissues. Coordinated interaction between the MT-IA and MT-IB isoforms was hypothesized based on the finding that MT-IA represented a primary action under ‘less stressful’ or ‘sublethal’ conditions, whereas the activation of MT-IB became important under ‘more stressful’ or ‘lethal’ circumstances in this species.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Andrews GK / 2000 / Regulation of metallothionein gene expression by oxidative stress and metal irons / Bio-chem Pharmacol 59 : 95 ~ 104
Bang In-Chul / 2007 / Effects of Acute Metal Exposures on the Viability and mRNA Expression of Metallothionein in Hemibarbus mylodon Fry / 한국하천호수학회지 40 (4) : 489 ~ 4
Bi Y / 2006 / Super induction of metallothionein I by inhibition of protein synthesis: role of a labile repressor in MTF-I media-ted gene transcription / J Biochem Mol Toxico
Bourdineaud JP / 2006 / Challenging the model for induction of metallothionein gene expression / Biochimie 88 : 1787 ~ 1792
Chen WY / 2004 / Expression of metallothionein gene during embryonic and early larval development in zebrafish / Aquat Toxicol 69 : 215 ~ 227
Bang In-Chul / 2007 / Effects of Acute Metal Exposures on the Viability and mRNA Expression of Metallothionein in Hemibarbus mylodon Fry / 한국하천호수학회지 40 (4) : 489 ~ 4
Bi Y / 2006 / Super induction of metallothionein I by inhibition of protein synthesis: role of a labile repressor in MTF-I media-ted gene transcription / J Biochem Mol Toxico
Bourdineaud JP / 2006 / Challenging the model for induction of metallothionein gene expression / Biochimie 88 : 1787 ~ 1792
Chen WY / 2004 / Expression of metallothionein gene during embryonic and early larval development in zebrafish / Aquat Toxicol 69 : 215 ~ 227
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