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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 409 - 418 (10page)
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In Korea, Rhus verniciflua Stokes is used to purge hardness, alleviate blood stasis, and treat cancer. However, the mechanisms of related anti-cancer activity are not fully understood in human cancer cells. This study investigated the anti-cancer effects and mechanisms of Rhus verniciflua Stokes on MDA-MB-231 human breast cancer cells and found that treatment with a Rhus verniciflua Stokes extract resulted in time- and concentration-responses that indicated growth inhibition of breast cancer cells by induced apoptosis. This was followed by a decrease in mitochondrial membrane potential; the activation of caspase-3, -8, and -9; and the up-regulation of tBid. Caspase-dependent apoptosis was induced through the inhibition of phosphatidylinositol 3-kinase (PI3K) and the Akt signaling pathway. This study provides evidence that Rhus verniciflua Stokes might be useful for the treatment of breast cancer.
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참고문헌 (21)
참고문헌 신청
Clarke BL / 2009 / New selective estrogen and androgen receptor modulators / Curr Opin Rheumatol 21 (4) : 374 ~ 379
Cohen GM / 1997 / Caspases: the executioners of apoptosis / Biochem J 326 : 1 ~ 16
Engelman JA / 2009 / Targeting PI3K signalling in cancer: opportunities, challenges and limitations / Nat Rev Cancer 9 (8) : 550 ~ 562
Feng Y / 2011 / Recent progress on anticancer candidates in patents of herbal medicinal products / Recent Pat Food Nutr Agric 3 (1) : 30 ~ 48
Kitt DD / 2001 / Antitumorigenic and cytotoxic properties of an ethanol extract derived from Rhus verniciflua Stokes(乾漆) / Journal of Toxicology and Environmental Health P
Cohen GM / 1997 / Caspases: the executioners of apoptosis / Biochem J 326 : 1 ~ 16
Engelman JA / 2009 / Targeting PI3K signalling in cancer: opportunities, challenges and limitations / Nat Rev Cancer 9 (8) : 550 ~ 562
Feng Y / 2011 / Recent progress on anticancer candidates in patents of herbal medicinal products / Recent Pat Food Nutr Agric 3 (1) : 30 ~ 48
Kitt DD / 2001 / Antitumorigenic and cytotoxic properties of an ethanol extract derived from Rhus verniciflua Stokes(乾漆) / Journal of Toxicology and Environmental Health P
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