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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 505 - 518 (14page)
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Objectives: This study was undertaken to investigate the effects of Gugijagami-bang (GGB) in a hyperlipidemic animal model induced by a high-fat diet using diverse biological methods.
Methods: This study was to determine whether fractionated GGB extracts inhibit reactive oxygen species (ROS) and nitric oxide (NO) in RAW 264.7 cells. Hyperlipidemia was induced by a high-fat diet fed for 6 weeks. Total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride, liver function and histologic change of liver were measured after oral administration of GGB.
Results:1. DPPH scavenging bow performance was increased in a concentration-dependent manner by GGB.
2. Compared to the control group, NO production (%) and ROS production (%) were decreased significantly by GGB.
3. Total-cholesterol, LDL-cholesterol, triglyceride were decreased significantly by GGB.
4. HDL cholesterol increased more than the control group, but not significantly.
5. In histopathologic examination, fatty liver (hepatic steatosis) was inhibited, almost no rounds of fat were observed in the liver.
Conclusions: GGB would appear effective in the prevention and treatment of atherosclerosis, ischemic heart disease, other cardiovascular diseases caused by hyperlipidemia.
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참고문헌 (41)
참고문헌 신청
Christopher KG / 2001 / Atherosclerosis: The road ahead / Cell 104 (4) : 503 ~ 516
Guerin M / 1996 / Fenofibrate reduces plasma cholesterol ester transfer from HDL to VLDL and normalizes the atherogenic. dense LDL profile in combined hyperlipidemia / Arter
Lee KU / 1988 / Artificial induction of intravascular lipolysis by lipidheparin infusion leads to insulin resistance in man / Diabetologia 31 (5) : 285 ~ 290
Nielsen S / 1997 / Obesity and Cardivascular disease is body structure a factor / Curr Opin Lipidol 8 (4) : 200 ~ 204
Packard CJ / 2000 / Apolipoprotein Bmetabolism and the distribution of VLDL and LDL subfractions / J lipid Res 41 : 305 ~ 318
Guerin M / 1996 / Fenofibrate reduces plasma cholesterol ester transfer from HDL to VLDL and normalizes the atherogenic. dense LDL profile in combined hyperlipidemia / Arter
Lee KU / 1988 / Artificial induction of intravascular lipolysis by lipidheparin infusion leads to insulin resistance in man / Diabetologia 31 (5) : 285 ~ 290
Nielsen S / 1997 / Obesity and Cardivascular disease is body structure a factor / Curr Opin Lipidol 8 (4) : 200 ~ 204
Packard CJ / 2000 / Apolipoprotein Bmetabolism and the distribution of VLDL and LDL subfractions / J lipid Res 41 : 305 ~ 318
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