지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Objective: This is a prospective clinical case study that includes the administration of Ahnjeonbaekho-tang (AJBHT) to patients who have suffered from Graves' disease for the 8 weeks of the clinical research. Methods: Without administration of an antithyroid drug, AJBHT was administered 3 times a day for 8 weeks. In Case 1, AJBHT without modification was administered and in Case 2, in accordance with the patients’ symptoms, a dose of Gypsum Fibrosum was increased by 4g from the beginning of week 2, and further increased by 16 g, for a total of 20 g between week 6 and week 8. Body mass index (BMI), thyroid function test (TFT), thyroid autoantibody test, complete blood cell count (CBC), and blood chemistry (BC) tests were conducted at an interval of 4 weeks, for a total of 3 times during the study. The clinical manifestations, a spectrum of symptoms of the patients, was observed by Wayne’s Index, Euro-QOL-5 Dimension (EQ-5D), and Perceived Stress Scale (PSS). Results: In both cases, an acceptable significance of reduction of value in T3, fT4, Thyroid stimulating antibody (TSAb) and Thyroid stimulating hormone receptor antibody (TSH-R-Ab) was observed. After treatment, in TFT, T3 decreased by 31.66%, fT4 decreased by 32.82% in Case 1, and T3 decreased by 43.42%, and fT4 decreased by 37.32% in Case 2. In the thyroid autoantibody test, TSAb decreased by 7.59%, and TSH-R-Ab decreased by 53.19% in Case 1, and TSAb decreased by 33.45%, TSH-R-Ab decreased by at least 7.75% in Case 2. Besides this, there was a decreasing trend of Wayne’s index, and a loss of typical symptoms of hyperthyroidism also declared the efficacy. Conclusion: From these results, AJBHT is very effective in the regulation of TFT and improving the symptoms of hyperthyroidism, and is also expected to be an effective alternative to antithyroid drugs for patients who have side effects or drug intolerance.
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등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Burch HB / 2015 / Management of Graves Disease: A Review / JAMA 314(23):2544~2554
이가희 / 2013 / 갑상선기능항진증의 진단 및 치료- 대한갑상선학회 합의안 / International Journal of Thyroidology 6(1):1~11
The Korean Association of Internal Medicine / 2012 / Harrison's Principles of Internal Medicine, 17th :2691
Heidari R / 2015 / An Overview on the Proposed Mechanisms of Antithyroid Drugs-Induced Liver Injury / Adv Pharm Bull 5(1):1~11
김경원 / 2007 / 항갑상선제 치료 후 그레이브스병의 재발 지표 분석 / 대한내과학회지 72(5):522~528
이가희 / 2013 / 갑상선기능항진증의 진단 및 치료- 대한갑상선학회 합의안 / International Journal of Thyroidology 6(1):1~11
The Korean Association of Internal Medicine / 2012 / Harrison's Principles of Internal Medicine, 17th :2691
Heidari R / 2015 / An Overview on the Proposed Mechanisms of Antithyroid Drugs-Induced Liver Injury / Adv Pharm Bull 5(1):1~11
김경원 / 2007 / 항갑상선제 치료 후 그레이브스병의 재발 지표 분석 / 대한내과학회지 72(5):522~528
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