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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 877 - 890 (14page)
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초록· 키워드
오류제보하기
Objectives: Lonicerae flos (LF), a dried flower part of Lonicera japonica Thunb., has been widely used in Korean medicine as anti-inflammatory and antioxidative agent. The purpose of this study was to determine the cardioprotective effects of LF, through potential antioxidant effects, on the pressure overload (PO)-induced heart failure (HF) in C57BL/6 mice after transverse aortic constriction (TAC) surgery.
Methods: Resveratrol (10 mg/kg body weight) or LF (125, 250 or 500 mg/kg body weight) was orally administered, once daily for 14 days, starting 14 days after TAC surgery. Changes in the mortality, body weights, heart weights, histopathology of the heart, and antioxidant defense systems of the heart were analyzed.
Results: Marked and noticeable increases of heart weights, mortalities, and hypertrophic, focal, and lytic fibrotic histological changes in the LVs were observed, with destruction of heart antioxidant defense systems after surgery. However, HF signs, induced by TAC surgery through PO, and destruction of heart antioxidant defense systems were significantly and dose-dependently inhibited by 14 days of maintained oral treatment with LF 500, 250 or 125 mg/kg. Treatment with 250 mg/kg LF was comparable to treatment with 10 mg/kg resveratrol.
Conclusions: The results in this study suggest that oral administration of LF favorably relieves PO-induced HF following TAC, through increase of heart antioxidant defense systems. The overall effects of 250 mg/kg LF were similar to those of 10 mg/kg resveratrol. More detailed mechanistic studies should be conducted in the future, with screening of the biologically active compounds in LF.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Juric D / 2007 / Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol / Am J Physiol Heart Circ Physiol 292(5):H2138~H2143
Wojciechowski P / 2010 / Resveratrol arrests and regresses the development of pressure overloadbut not volume overload-induced cardiac hypertrophy in rats / J Nutr 140(5):962~968
Yu S / 2010 / MicroRNA expression and function in cardiac ischemic injury / J Cardiovasc Transl Res 3(3):241~245
Dai DF / 2012 / Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress / Cardiovasc Res 93(1):79~88
Koga K / 2013 / Macrophage migration inhibitory factor antagonizes pressure overload-induced cardiac hypertrophy / Am J Physiol Heart Circ Physiol 304(2):H282~H293
Wojciechowski P / 2010 / Resveratrol arrests and regresses the development of pressure overloadbut not volume overload-induced cardiac hypertrophy in rats / J Nutr 140(5):962~968
Yu S / 2010 / MicroRNA expression and function in cardiac ischemic injury / J Cardiovasc Transl Res 3(3):241~245
Dai DF / 2012 / Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress / Cardiovasc Res 93(1):79~88
Koga K / 2013 / Macrophage migration inhibitory factor antagonizes pressure overload-induced cardiac hypertrophy / Am J Physiol Heart Circ Physiol 304(2):H282~H293
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