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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives : The object of this study was to obtain acute information (single oral dose toxicity) of Scutellariae Radix Aqueous Extracts (SR; yield = 27.20%) which traditionally have been used in Korean medicine for treating various diseases including inflammatory diseases.
Methods : In order to observe the 50% lethal dose (LD50), approximate lethal dosage (ALD) and target organs, SR Aqueous Extracts were once orally administered to female and male ICR mice at dose levels of 2,000, 1,000, 500 and 0 (control) mg/kg (body weight.) according to the recommendation of KFDA Guidelines. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after single oral treatment of SR according to KFDA Guidelines with organ weights and histopathological observations of 14 types of principle organs.
Results : After single oral treatment of SR, we could not find any mortality and toxicological evidences up to 2,000 mg/kg treated group, the limited dosages in rodents, on the body and organ weights, clinical signs, gross and histopathological observations, except for some accidental findings.
Conclusions : The results obtained in this study suggest that the LD50 and ALD of SR in both female and male mice after single oral treatment be considered as over 2,000 mg/kg because no mortalities were detected up to 2,000 mg/kg that was the highest dose recommended by KFDA and OECD, and can be safely used in clinics.
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참고문헌 (28)
참고문헌 신청
Aung H / 2005 / Scutellaria baicalensis decreases ritonavir-induced nausea / AIDS Res Ther 20 (2) : 12 ~
Chen LG / 2008 / Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells / Mol Nutr Food R
Chu M / 2007 / The extract of compound Radix Scutellariae on mRNA replication and IFN expression of influenza virus in mice / Zhong Yao Cai 30 : 63 ~ 65
Department of Health, Education, and Welfare Publication(National Institute of Health) / 1985 /
Haouzi D / 2000 / Cytochrome P450-generated reactive metabolites cause mitochondrial permeability transition, caspase activation, and apoptosis in rat hepatocyte / Hepatolog
Chen LG / 2008 / Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells / Mol Nutr Food R
Chu M / 2007 / The extract of compound Radix Scutellariae on mRNA replication and IFN expression of influenza virus in mice / Zhong Yao Cai 30 : 63 ~ 65
Department of Health, Education, and Welfare Publication(National Institute of Health) / 1985 /
Haouzi D / 2000 / Cytochrome P450-generated reactive metabolites cause mitochondrial permeability transition, caspase activation, and apoptosis in rat hepatocyte / Hepatolog
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