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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 302 - 312 (11page)
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이 논문의 연구 히스토리 (3)
2018
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Objectives: This study was performed to investigate the effects of two herbal medicines, Agastachis Herba and Lysimachiae Herba, on a cellular model of non-alcoholic fatty liver diseases (NFLDs). Methods: HepG2 cells were treated with palmitic acid and with various concentrations of Agastachis Herba (AH) or Lysimachiae Herba (LH) extract in water. The lipotoxicity was assessed using EZ-cytox, and the lipoapoptosis was assessed using cell death detection ELISA. Intracellular lipids were measured by oil red O staining. The efficacy of AH and LH on sterol regulatory element-binding transcription factor-1c (SREBP-1c), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC) in HepG2 cells was measured by reverse transcription polymerase chain reaction (RT-PCR). Results: Both AH and LH extracts increased lipoapoptosis and decreased lipotoxicity and levels of SREBP-1c, ACC, and FAS (SREBP-1c, ACC, and FAS are factors in lipid synthesis). In the oil red O staining experiment, both extracts also reduced intracellular lipid accumulation; in this instance, LH’s efficacy was superior to that of AH. Conclusions: According to the results, both AH and LH are likely to contribute to non-alcoholic fatty liver disease, as both interfere with lipid synthesis.
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참고문헌 (25)
참고문헌 신청
Department of Internal Medicine, Medical school of Seoul University / 2005 / 2005 recent Advances in Internal Medicine / Korean Medical book Publishing :138~149
Foster C / 2012 / The Washington Manual of Medical Therapeutics, 33rd edition / Shinheung Medscience :711~713
Rhee EJ / 2017 / Clinical Characteristics of Non-Alcoholic Fatty Liver Disease Based on Analyses from the Kangbuk Samsung Health Study / J Korean Diabetes 18(2):82~87
The Korean Association for the Study of the Liver / 2013 / Non-Alcoholic Fatty Liver Disease Guidelines, 1st edition / Jin Publishing :1
Jo JH / 2012 / Road Map Clinical Internal Medicine, 1st edition / Panmun Education :80
Foster C / 2012 / The Washington Manual of Medical Therapeutics, 33rd edition / Shinheung Medscience :711~713
Rhee EJ / 2017 / Clinical Characteristics of Non-Alcoholic Fatty Liver Disease Based on Analyses from the Kangbuk Samsung Health Study / J Korean Diabetes 18(2):82~87
The Korean Association for the Study of the Liver / 2013 / Non-Alcoholic Fatty Liver Disease Guidelines, 1st edition / Jin Publishing :1
Jo JH / 2012 / Road Map Clinical Internal Medicine, 1st edition / Panmun Education :80
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