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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 180 - 188 (9page)
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초록· 키워드
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Objectives: This study investigated the effects of Paljeong-san on chronic nonbacterial prostatitis induced in rats by estradiol.
Methods: Rats were divided into three groups. The normal group included rats with no intervention after sham castration. The control group included rats with prostatitis induced by 17β-estradiol after orchiectomy; these rats were orally administered normal saline. The sample group rats were administered Paljeong-san after prostatitis induction. Evaluations included changes in epithelial score, body weight, and prostate weight and volume, as well as histopathological changes in prostate tissue and gene expression of TNF-α, COX-2, and CD68.
Results: Paljeong-san inhibited histopathological changes and monocyte/macrophage infiltration of the prostate. The epithelial score was higher for the sample group than for the control group (P<0.05). Paljeong-san administration decreased the gene expression of TNF-α and CD68.
Conclusions: Paljeong-san shows prostate-protective effects by inhibiting infiltration by monocytes/macrophages and by reducing TNF-α gene expression.
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참고문헌 (24)
참고문헌 신청
/ 2003 / Effects of androgen deprivation on chronic bacterial prostatitis in a rat model / Int J Urol 10 : 485 ~ 491
Ahn YM / 1995 / The study of oriental and accidental benign prostste hypertrophy / J of Oriental Chr Dis 1 : 85 ~ 112
Andriole VT / 1991 / Use of quinolones in treatment of prostatitis and lower urinary tract infections / Eur J Clin Microbiol Infect Dis 10 : 342 ~ 350
Angwafo FF 3rd / 2003 / The National Health Survey Team for The National Epidemiology Board of Cameroon. High-grade intra-epithelial neoplasia and prostate cancer in Dibombar
Koo HJ / 2004 / Antiinflammatory effects of genipin, an active principle of gardenia / Eur J Pharmacol 495 (2) : 201 ~ 208
Ahn YM / 1995 / The study of oriental and accidental benign prostste hypertrophy / J of Oriental Chr Dis 1 : 85 ~ 112
Andriole VT / 1991 / Use of quinolones in treatment of prostatitis and lower urinary tract infections / Eur J Clin Microbiol Infect Dis 10 : 342 ~ 350
Angwafo FF 3rd / 2003 / The National Health Survey Team for The National Epidemiology Board of Cameroon. High-grade intra-epithelial neoplasia and prostate cancer in Dibombar
Koo HJ / 2004 / Antiinflammatory effects of genipin, an active principle of gardenia / Eur J Pharmacol 495 (2) : 201 ~ 208
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