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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 119 - 132 (14page)
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Objectives : This study was undertaken to investigate the effects of Samulhwalhyeol-tang (SM) in a hyperlipidemic animal model induced by a high-fat diet using diverse biological methods.
Methods : This study was to determine whether fractionated EtOH extracts of SM inhibit reactive oxygen species (ROS) and nitric oxide (NO) in RAW 264.7 cells. Hyperlipidemia was induced by a high-fat diet fed for 6 weeks. Total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride, glucose, liver function, cholesterol gene revelation control efficiency, and histologic change of liver were measured after oral administration of SM.
Results :1. Compared to the control group, ROS production (%) and NO production (%) were decreased significantly by SM.
2. Total cholesterol, LDL cholesterol, triglyceride were decreased significantly by SM.
3. HDL cholesterol was increased significantly by SM.
4. Rats' body weight and glucose were decreased significantly by SM.
5. AST, ALP were decreased significantly by SM.
6. In histopathologic examination, fatty liver and fiver fibrosis were inhibited, almost eliminated as round of fat was observed in the liver.
Conclusions : SM would appear that effective in the prevention and treatment of atherosclerosis, ischemic heart disease, other cardiovascular diseases, fatty liver and nephrotic syndrome caused by hyperlipidemia.
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참고문헌 (36)
참고문헌 신청
Bjorntorp P / 1988 / The associations between obesity, adipose tissue distribution and disease / Acta Med Scand Suppl 723 : 121 ~ 134
Channon KM / 2000 / Nitric oxide synthase in atherosclerosis and vascular injury: insights from experimental gene therapy / Arterioscler Thromb Vasc Biol 20 : 1873 ~ 1881
Chun SI / 1999 / The risk groups for coronary heart disease in Koreans. Assessment by distribution of serum lipid concentrations / Clin Chem Lab Med 37 (10) : 969 ~ 974
Daniel J. Rader / 2006 / Harrison’s Principles of Internal medicine. Section 3 Disorders of Intermediary Metabolism / MIP : 2038 ~ 2040
Kim JQ / 1997 / National cholesterol treatment guidelines in Korean population-setting-up the cutpoints for high blood cholesterol- / J Korean Med Sci 12 : 17 ~ 22
Channon KM / 2000 / Nitric oxide synthase in atherosclerosis and vascular injury: insights from experimental gene therapy / Arterioscler Thromb Vasc Biol 20 : 1873 ~ 1881
Chun SI / 1999 / The risk groups for coronary heart disease in Koreans. Assessment by distribution of serum lipid concentrations / Clin Chem Lab Med 37 (10) : 969 ~ 974
Daniel J. Rader / 2006 / Harrison’s Principles of Internal medicine. Section 3 Disorders of Intermediary Metabolism / MIP : 2038 ~ 2040
Kim JQ / 1997 / National cholesterol treatment guidelines in Korean population-setting-up the cutpoints for high blood cholesterol- / J Korean Med Sci 12 : 17 ~ 22
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