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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 726 - 737 (12page)
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Objective: In order to investigate cell death mechanism by Gunbibosinhangam-Tang(G.B.H) in cancer cells, the activities of apoptosis signaling pathway were tested in human neuroblastoma cell line BE2.Methods: Viability of BE2 cells was markedly decreased by treatment of the water extract of G.B.H in a dose-dependent manner. G.B.H-induced cell death was confirmed as apoptosis characterized by chromatin condensation. We tested whether the water extract of G.B.H effects the anti-apoptotic proteins such as Bcl-XL.Results: Bcl-XL was uneffected by the addition of the water extract of G.B.H. in a time-dependent manner. Cleavage of PARP(poly-ADP-ribose polymerase) by activation of caspase-8 protease was also observed in BE2 cells by the treatment of the water extract of G.B.H.Conclusion: These results suggest that the water extract of G.B.H exerts anti-cancer effects on human neuroblastoma BE2 cells by inducing the apoptotic death via activation of intrinsic caspase cascades.
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참고문헌 (24)
참고문헌 신청
/ 1994 / 抗癌劑 및 放射線 副作用에 대한 韓方療法 9 : 239 ~ 64
/ 1996 / Involvement of the CD95 APO1 FAS receptor ligand system in druginduced apoptosis in Leukemia cells 2 : 574 ~ 577
/ 1997 / Cytochrome c activation of CPP32 like proteolysis plays a critical role in a Xenopus cell free apoptosis system 16 : 4639 ~ 4649
/ 1997 / HARRISION's principle of internal medicine (II) : 1963 ~ 1977
/ 1997 / Overexpression of Bcl xL inhibits Ara C induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis 57 : 311
/ 1996 / Involvement of the CD95 APO1 FAS receptor ligand system in druginduced apoptosis in Leukemia cells 2 : 574 ~ 577
/ 1997 / Cytochrome c activation of CPP32 like proteolysis plays a critical role in a Xenopus cell free apoptosis system 16 : 4639 ~ 4649
/ 1997 / HARRISION's principle of internal medicine (II) : 1963 ~ 1977
/ 1997 / Overexpression of Bcl xL inhibits Ara C induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis 57 : 311
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