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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The intent of this study is to investigate whether two oriental medical prescriptions named haengsotang(HST) and gami-palmihwan (GPMH) significantly effect mucin release from cultured hamster tracheal surface epithelial(HTSE) cells. Confluent HTSE cells were metabolically radiolabeled with 3H-glucosamine for 24 hrs and chased for 30 min in the presence of HST or GPMH to assess the effect of each agent on 3H-mucin release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase(LDH) release. Also, the effects of HST and GPMH on contractility of isolated tracheal smooth muscle were investigated. The results are consistant with the following assertions : (1) HST significantly inhibited mucin release from cultured HTSE cells, without cytotoxicity ; (2) GPMH did not effect mucin release without cytotoxicity; (3) HST and GPMH did not effect contractility of isolated tracheal smooth muscle. These results suggest a need for further investigation of HST and its components, for its potential in oriental medicine prescriptions and novel agents that effectively regulate (inhibit) mucin secretion from airway goblet cells.
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참고문헌 (12)
참고문헌 신청
/ 1981 / Elevated levels of the eosinophil granule major basic protein in the sputum of patients with bronchial asthma 56 (6) : 345 ~ 53
/ 1982 / Continuous multiplication of rabbit tracheal epithelial cells in a defined,homone-supplemented medium 18 (9) : 800 ~ 12
/ 1983 / Textbook of Pulmonary Disease
/ 1985 / Biochemical characterization of mucous glycoproteins synthesized and secreted by hamster tracheal epithelial cells in primary culture 260 (7) : 4021 ~ 7
/ 1985 / Possible requirement of collagen gel substratum for production of mucinlike glycoproteins by primary rabbit tracheal epithelial cells in culture 21 (11) : 617 ~ 21
/ 1982 / Continuous multiplication of rabbit tracheal epithelial cells in a defined,homone-supplemented medium 18 (9) : 800 ~ 12
/ 1983 / Textbook of Pulmonary Disease
/ 1985 / Biochemical characterization of mucous glycoproteins synthesized and secreted by hamster tracheal epithelial cells in primary culture 260 (7) : 4021 ~ 7
/ 1985 / Possible requirement of collagen gel substratum for production of mucinlike glycoproteins by primary rabbit tracheal epithelial cells in culture 21 (11) : 617 ~ 21
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