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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 93 - 104 (12page)
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Objectives : The aim was to identify the inhibitory effects of Liriopis Tuber on bleomycin-induced lung fibrosis by analysing the changes of imflammatory cell cytokines and SHI(Semiquantitative Histological Index).Materials and Methods : In this study fibrosis prone C57BL/6J mice were used. Control group was treated with blomycin(0.06㎎/0.1㎖) by IT(intratracheal) instillation which is a popular method of inducing lung fibrosis and sample group took Liriopis Tuber water extract(38.0㎎/10g body weight) orally for 14 days after IT instillation of blomycin. We measured the total and differential count of WBC, IFN-γ & IL-4 in mice BALF and SHI(Semiquantitative Histological Index) from lung tissues of mice. BALF and lung tissues of mice were taken 14 days after IT instillation of blomycin.Results : In sample group total WBC count, proportion of neutrophil, SHI and IL-4 significantly(p<0.05) decreased, proportion of macrophage significantly(p<0.05) increased and proportion of lymphocyte, IFN-γ did not decrease significantly.Conclusions : This study suggests that Liriopis Tuber has an inhibitory effects of pulmonary fibrosis by attenuation of inflammation and Th2 immune response. To determine whether this herbal medicine contribute to cure and prophylaxis of pulmonary fibrosis, further studies on the role of IFN-γ relating to fibrosis are required.
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참고문헌 (21)
참고문헌 신청
/ 1990 / 각종 간질성 폐질환에서 폐포 대식세포의 Superoxide분비능과 식균 작용 39 (3) : 325 ~ 32
/ 1993 / PCR analysis of cytokine induction profiles associated with mouse strain variation in susceptibility to pulmonary fibrosis 5 (34) : 207 ~ 17
/ 1993 / Pathogenesis of idiopathic interstitial pneumonia/idiopathic pulmonary fibrosis:cellular and molecular biology of the disease suppl : 20 ~ 31
/ 1995 / pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic fibrosing alveolitis 101 (l) : 436 ~ 441
/ 1996 / Interleukin-4 and interferon-γ discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets 167 (2) : 290 ~ 296
/ 1993 / PCR analysis of cytokine induction profiles associated with mouse strain variation in susceptibility to pulmonary fibrosis 5 (34) : 207 ~ 17
/ 1993 / Pathogenesis of idiopathic interstitial pneumonia/idiopathic pulmonary fibrosis:cellular and molecular biology of the disease suppl : 20 ~ 31
/ 1995 / pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic fibrosing alveolitis 101 (l) : 436 ~ 441
/ 1996 / Interleukin-4 and interferon-γ discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets 167 (2) : 290 ~ 296
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