지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 37 - 49 (13page)
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초록· 키워드
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Objectives
Idiopathic pulmonary fibrosis (IPF) is chronic fibrotic interstitial pneumonia and the pathogenesis is unknown. Peucedani Radix is well-known for the treatment of respiratory diseases and pulmonary hypertension. This study was to evaluate the effectiveness of Peucedani Radix on the bleomycin-induced lung fibrosis model (BLFM) in mouse.
Methods
We induced lung fibrosis by intratracheal instillation of bleomycin in C57BL/6J. We compared two groups BLFM without Peucedani Radix (group I) and BLFM with Peucedani Radix (group Ⅱ). We performed bronchoalveolar lavages (BAL) and obtained lung specimens from both group I and Ⅱ on the 7th (A) and 21st (B) day, and also for the normal group. We compared with group I and Ⅱ to find BAL by using ANOVA test and to find pathologic symptoms by using semiquantitative histological index (SHI).
Results
In BAL, total cell counts, lymphocytes, and neutrophils was increased in both group I and Ⅱ comparing with normal group. However, lymphocyte level was decreased more in group ⅡB than group IB. It was statistically significant. In microscopic findings, scores of SHI in normal group, group IB and ⅡB were 0.33, 4.47, and 1.96 each.
Conclusions
Peucedani Radix might have inhibitory effect on lung fibrosis by reducing inflammatory cells in bleomycin-induced lung fibrosis model in mouse.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Alvarez-Sala R / 1993 / Idiopathic pulmonary fibrosis: new diagnosis and therapethetic perspective / An Med Interna 10 (7) : 355 ~ 360
American Thoracic Society / 2002 / Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society(ATS), and the European
Berkman N / 2001 / Human recombinant interferon-alpha2a and interferon-alphaA/D have different effects on bleomycin-induced lung injury / Respiration 68 (2) : 169 ~ 177
British Thoracic Society: Standards of Care Committee / 1999 / The diagnosis, assessment and treatment of diffuse parenchymal lung disease in adults / Thorax 54 (1) : S1S30 ~
Chang KW / 2003 / Idiopathic pulmonary fibrosis in a child / Hang Gung Med J 26 (1) : 60 ~ 64
American Thoracic Society / 2002 / Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society(ATS), and the European
Berkman N / 2001 / Human recombinant interferon-alpha2a and interferon-alphaA/D have different effects on bleomycin-induced lung injury / Respiration 68 (2) : 169 ~ 177
British Thoracic Society: Standards of Care Committee / 1999 / The diagnosis, assessment and treatment of diffuse parenchymal lung disease in adults / Thorax 54 (1) : S1S30 ~
Chang KW / 2003 / Idiopathic pulmonary fibrosis in a child / Hang Gung Med J 26 (1) : 60 ~ 64
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