지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Object : In condition of brain infarction, irreversible axon damage occurs in central nerve system (CNS), because gliosis makes physical and mechanical barrier. If gliosis formation could be suppressed, irreversible axon damage would be reduced. This could mean that injured CNS could be regenerated. CD81 and GFAP has close relation to gliosis. The increase in glial cells at injured CNS gives rise to the expression of CD81 and GFAP. CD81 was postulated to play a central role in the process of CNS scar formation.
Method : So in this study, the author investigated the effect of the water extract of the Moutan Radicis Cortex on regulation of CD81 and GFAP expression in injured CNS cells.
MTT assay was used to examine cell viability, and RT-PCR and ELISA methods were carried out to measure the expression of CD81 and GFAP in the astrocyte.
Results : We observed that water extract of the Moutan Radicis Cortex increased cell viability under hypoxia induced by CoCl2 and suppressed the expression of CD81 and GFAP up-regulated by hypoxia.
Conclusion : In conclusion, these results suggest that the Moutan Radicis Cortex could promote neural regeneration as a consequence of protecting CNS cells from hypoxia and suppressing the reactive gliosis following CNS injury
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bethea JR / 1999 / Systemically administered interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic
Broude E / 1999 / Fetal spinal cord transplants and exogenous neurotrophic support enhance c-Jun expression in mature axotomized neurons after spinal cord injury / Exp Neuro
Dijkstra S / 2006 / Intraspinal administration of an antibody against CD81 enhances functional recovery and tissue sparing after experimental spinal cord injury / Exp Neurol
Dijkstra, S / 2000 / Upregulation of CD81 (target of the antiproliferative antibody, TAPA) by reactive microglia and astrocytes after spinal cord injury in the rat / J. Comp.
Dusart I / 1994 / Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord / Eur J Neurosci 6 : 712 ~ 724
Broude E / 1999 / Fetal spinal cord transplants and exogenous neurotrophic support enhance c-Jun expression in mature axotomized neurons after spinal cord injury / Exp Neuro
Dijkstra S / 2006 / Intraspinal administration of an antibody against CD81 enhances functional recovery and tissue sparing after experimental spinal cord injury / Exp Neurol
Dijkstra, S / 2000 / Upregulation of CD81 (target of the antiproliferative antibody, TAPA) by reactive microglia and astrocytes after spinal cord injury in the rat / J. Comp.
Dusart I / 1994 / Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord / Eur J Neurosci 6 : 712 ~ 724
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