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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives : Asthma is a chronic inflammatory disorder of the airways by many cells such as mast cells, Th2 lymphocyte and eosinophils. The present study was aimed to evaluate the effects of Salviae miltiorrhizae(SM) on T cell cytokine production, mast cells, eosinophils.
Methods : We screened 13 herbs to find compounds with potential to control Th cytokine production, using concanavalin A (con A)-activated splenocyte cultures. Con A-activated IFN-γ and IL-4 levels in supernatants of splenocyte cultures. Bone marrow derived mast cell (BMMC)s were incubated with SM and then the expressions of membrane proteins of BMMC were analyzed by fluorescence activated cell sorter (FACS). BALB/c mice sensitized to ovalbumin (OVA) were challenged with aerosolized OVA for 6weeks. During the last weeks some mice were treated with SM. Then eosinophils in bronchoalveolar lavage fluid (BALF) were counted and pathologic changes of lung tissue were observed with hematoxylin-eosin stain.
Results : SM increased IFN-γ level on splenocyte culture significantly. But SM had no significant effects on expressions of ICAM-1, CD62L, integrin α4, c-kit, IL-3 receptor, CD11a, IgE receptor of BMMC. And SM treatment significantly inhibited eosinophil infiltrates in BALF and peribronchial lung inflammation.
Conculusions : The present data suggested that SM may have an effect on Th cytokine secretion and eosinophils associated with asthma responses. Therefore SM might be of therapeutic value in treating asthma.
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참고문헌 (28)
참고문헌 신청
Abbas AK / 2000 / Cellular and Molecular Immunology. 4th ed. / W.B Saunders : 260 ~ 261
Abraham WM / 1994 / Alpha 4-integrins media
Bateman ED / 2008 / Global strategy for asthma management and prevention: GINA executive summary / Eur Respir J 31 (1) : 143 ~ 178
Bhattacharyya SP / 1998 / Activated T lymphocytes induce degranulation and cytokine production by human mast cells following cell-to-cell contact / J Leukoc Biol 63 (3) : 33
Gauvreau GM / 2003 / The effects of an anti-CD11a mAb, efalizumab, on allergen- induced airway responses and airway inflammation in subjects with atopic asthma / J Allergy C
Abraham WM / 1994 / Alpha 4-integrins media
Bateman ED / 2008 / Global strategy for asthma management and prevention: GINA executive summary / Eur Respir J 31 (1) : 143 ~ 178
Bhattacharyya SP / 1998 / Activated T lymphocytes induce degranulation and cytokine production by human mast cells following cell-to-cell contact / J Leukoc Biol 63 (3) : 33
Gauvreau GM / 2003 / The effects of an anti-CD11a mAb, efalizumab, on allergen- induced airway responses and airway inflammation in subjects with atopic asthma / J Allergy C
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