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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제5권 제1호
- 발행연도
- 2007.1
- 수록면
- 14 - 18 (5page)
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This mini-review focuses on the depression and suicide risk in patients with schizophrenia during the treatment by second generation antipsychotic drugs. Regarding depressive symptoms and depressive illness in schizophrenia, several studies have found a relationship between negative or positive symptoms and depressive symptoms. Also,“revealed depression”,“akinetic depression”, or“pharmacogenic depression” is reported to explain the presence of depression in schizophrenia. There are several good reasons to consider that second generation antipsychotic drugs may prove to have at least somewhat superior effects on depression in schizophrenia than first generation antipsychotic drugs: their relatively weak blockade at D2 receptors, minimal serum prolactin elevations, and minimal extrapyramidal symptoms. Regarding suicide in schizophrenia, depression is one
of the important factors for suicide. Second generation antipsychotic drugs particularly clozapine are thought to be effective for suicide in schizophrenia, via several proposed mechanisms including an antidepressant effect. Over all, second generation antipsychotic drugs are considered to be effective for both depression and suicide in schizophrenia. However, since patients would have strong psychological reactions to their symptom improvement, which would make a maladaptive or adaptive response, it should
be noted that changes in awareness associated with treatment be carefully monitored regardless of medications we choose.
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참고문헌 (30)
참고문헌 신청
. Washington / 1994. / American Psychiatric Association. Diagnostic and Statistical Ma-nual of Mental Disorders
/ / Galdi J. The causality of depression in schizophrenia. Br J Psy-chiatry 1983 : 621 ~ 624
/ / Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960 : 56 ~ 62
/ / Hirsch SR. Depresion revealed in schizophrenia. Br J Psy-chiatry 1982 : 421 ~ 423
/ / Miles CP. Conditions predisposing to suicide : 231 ~ 246
/ / Galdi J. The causality of depression in schizophrenia. Br J Psy-chiatry 1983 : 621 ~ 624
/ / Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960 : 56 ~ 62
/ / Hirsch SR. Depresion revealed in schizophrenia. Br J Psy-chiatry 1982 : 421 ~ 423
/ / Miles CP. Conditions predisposing to suicide : 231 ~ 246
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