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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제16권 제3호
- 발행연도
- 2018.1
- 수록면
- 235 - 245 (11page)
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Atypical antipsychotics (AAPs) are increasingly used for the treatment of psychotic disorders but are known to be associated with metabolic abnormalities. This study is a systematic review and meta-analysis of randomized controlled trials (RCTs) studying the effectiveness of melatonin for the amelioration of AAP-induced metabolic syndrome. The MEDLINE (accessed via PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials, PsycINFO, LILACS, CINAHL, and OpenGrey databases were searched for RCTs without language restrictions. Inclusion criteria were randomized, double-blind clinical trials comparing melatonin or melatonin agonists with placebo for the amelioration of AAP-induced effects at any age with selected components of metabolic syndrome as outcome measures. Two reviewers independently selected articles and assessed quality using Cochrane risk of bias and concealment tools. Of 53 records, five RCTs were eligible for the systematic review and three for the meta-analysis. The meta-analyses showed no statistically significant difference in any anthropometric or metabolic variable considered. Analysis according to psychiatric diagnosis from one RCT showed significant decreases in diastolic blood pressure (5.5 vs. −5.7 mmHg for the placebo and melatonin groups, respectively; p =0.001), fat mass (2.7 vs. 0.2 kg, respectively; p =0.032), and triglycerides (D) (50.1 vs. −20 mg/dl, respectively; p =0.08) in the bipolar group but not the schizophrenia group. Although limited to five RCTs with small sample sizes, evidence from RCT indicates that melatonin improves AAP-induced metabolic syndrome. This beneficial effect seems more significant in patients with bipolar disorder than those with schizophrenia. Further RCTs are needed to definitively establish the potential ameliorative effect of melatonin and to justify its efficacy as an add-on therapy to curtail AAP-induced metabolic syndrome.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Leo RJ / 2000 / Atypical antipsychotic use in the treatment of psychosis in primary care / Prim Care Companion J Clin Psychiatry 2:194~204
Calarge CA / 2009 / Weight gain and metabolic abnormalities during extended risperidone treatment in children and adolescents / J Child Adolesc Psychopharmacol 19:101~109
고유경 / 2013 / The Prevalence of Metabolic Syndrome in Schizophrenic Patients Using Antipsychotics / Clinical Psychopharmacology and Neuroscience 11(2):80~88
Deedwania PC / 2006 / Management issues in the metabolic syndrome / J Assoc Physicians India 54:797~810
Fontaine KR / 2001 / Estimating the consequences of anti-psychotic induced weight gain on health and mortality rate / Psychiatry Res 101:277~288
Calarge CA / 2009 / Weight gain and metabolic abnormalities during extended risperidone treatment in children and adolescents / J Child Adolesc Psychopharmacol 19:101~109
고유경 / 2013 / The Prevalence of Metabolic Syndrome in Schizophrenic Patients Using Antipsychotics / Clinical Psychopharmacology and Neuroscience 11(2):80~88
Deedwania PC / 2006 / Management issues in the metabolic syndrome / J Assoc Physicians India 54:797~810
Fontaine KR / 2001 / Estimating the consequences of anti-psychotic induced weight gain on health and mortality rate / Psychiatry Res 101:277~288
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