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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제13권 제1호
- 발행연도
- 2015.1
- 수록면
- 109 - 112 (4page)
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초록· 키워드
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Clozapine has been demonstrated to be useful for treating refractory schizophrenia. However, hypersalivation occurs in 31.0- 97.4% of the patients treated with clozapine. Accordingly, some patients who are disturbed by their hypersalivation refuse to continue with clozapine treatment. This study investigated the efficacy of the anticholinergic agent scopolamine butylbromide against clozapine-induced hypersalivation. Five schizophrenia patients were coadministered scopolamine butylbromide (30-60 mg/ day) for 4 weeks. At the baseline and after 4 weeks’ treatment, we subjectively evaluated hypersalivation using a visual analog scale and objectively assessed it using the Drooling Severity Scale and Drooling Frequency Scale. As a result, improvements in the patients’ Drooling Severity Scale and Drooling Frequency Scale scores, but no improvements in their visual analog scale scores, were observed after scopolamine butylbromide treatment. These results indicate that at least some schizophrenic patients with clozapine-induced hypersalivation would benefit from scopolamine butylbromide treatment. We conclude that clozapine-induced hypersalivation is one factor of stress to patients. Subjective hypersalivation was not improved, but objective hypersalivation was, by scopolamine butylbromide treatment. However, scopolamine butylbromide and clozapine possess anticholinergic effects so clinicians should closely monitor patients who take scopolamine butylbromide.
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등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Ancelin ML. / 2006 / Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs : longitudinal cohort study / BMJ 332 : 455 ~ 459
Bymaster FP. / 1996 / Radioreceptor binding profile of the atypical antipsychotic olanzapine / Neuropsychopharmacology 14 : 87 ~ 96
Calderon J. / 2000 / Potential use of ipatropium bromide for the treatment of clozapine-induced hypersalivation : a preliminary report / Int Clin Psychopharmacol 15 : 49 ~ 52
Davydov L. / 2000 / Clozapine-induced hypersalivation / Ann Pharmacother 34 : 662 ~ 665
Kishi T. / 2013 / Efficacy and tolerability of clozapine in Japanese patients with treatment-resistant schizophrenia : results from a 12-week, flexible dose study using rater
Bymaster FP. / 1996 / Radioreceptor binding profile of the atypical antipsychotic olanzapine / Neuropsychopharmacology 14 : 87 ~ 96
Calderon J. / 2000 / Potential use of ipatropium bromide for the treatment of clozapine-induced hypersalivation : a preliminary report / Int Clin Psychopharmacol 15 : 49 ~ 52
Davydov L. / 2000 / Clozapine-induced hypersalivation / Ann Pharmacother 34 : 662 ~ 665
Kishi T. / 2013 / Efficacy and tolerability of clozapine in Japanese patients with treatment-resistant schizophrenia : results from a 12-week, flexible dose study using rater
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