지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.7
- 수록면
- 211 - 219 (9page)
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초록· 키워드
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Background: Panax ginseng root is used in traditional oriental medicine for human health. Its main active components such as saponins and polysaccharides have been widely evaluated for treating diseases, but secondary active components such as oligosaccharides have been rarely studied. This study aimed to assess the impact of water-soluble ginseng oligosaccharides (WGOS), which were isolated from the warm-water extract of Panax ginseng root, on scopolamine-induced cognitive impairment in mice and its antineuroinflammatory mechanisms.
Methods: We investigated the impact of WGOS on scopolamine-induced cognitive impairment in mice by using Morris water maze and novel object recognition task. We also analyzed the impact of WGOS on scopolamine-induced inflammatory response (e.g., the hyperexpression of proinflammatory cytokines IL-1β and IL-6 and astrocyte activation) by quantitative real-time polymerase chain reaction and glial fibrillary acid protein (GFAP) immunohistochemical staining.
Results: WGOS pretreatment protected against scopolamine-induced learning and memory deficits in the Morris water maze and in the novel object recognition task. Furthermore, WGOS pretreatment downregulated scopolamine-induced hyperexpression of proinflammatory cytokines interleukin (IL)-1β and IL-6 mRNA and astrocyte activation in the hippocampus. These results indicate that WGOS can protect against scopolamine-induced alterations in learning and memory and inflammatory response.
Conclusion: Our data suggest that WGOS may be beneficial as a medicine or functional food supplement to treat disorders with cognitive deficits and increased inflammation.
Methods: We investigated the impact of WGOS on scopolamine-induced cognitive impairment in mice by using Morris water maze and novel object recognition task. We also analyzed the impact of WGOS on scopolamine-induced inflammatory response (e.g., the hyperexpression of proinflammatory cytokines IL-1β and IL-6 and astrocyte activation) by quantitative real-time polymerase chain reaction and glial fibrillary acid protein (GFAP) immunohistochemical staining.
Results: WGOS pretreatment protected against scopolamine-induced learning and memory deficits in the Morris water maze and in the novel object recognition task. Furthermore, WGOS pretreatment downregulated scopolamine-induced hyperexpression of proinflammatory cytokines interleukin (IL)-1β and IL-6 mRNA and astrocyte activation in the hippocampus. These results indicate that WGOS can protect against scopolamine-induced alterations in learning and memory and inflammatory response.
Conclusion: Our data suggest that WGOS may be beneficial as a medicine or functional food supplement to treat disorders with cognitive deficits and increased inflammation.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (33)
참고문헌 신청
[학술지(정기간행물)] - Kar S / 2004 / Interactions between betaamyloid and central cholinergic neurons: implications for Alzheimer’s disease / J Psychiatry Neurosci 29 : 427 ~ 441
[학술지(정기간행물)] - Ibach B / 2004 / Acetylcholinesterase inhibition in Alzheimer’s Disease / Curr Pharm Des 10 : 231 ~ 251
[학술지(정기간행물)] - Golde TE / 2006 / Disease modifying therapy for AD? / J Neurochem 99 : 689 ~ 707
[학술지(정기간행물)] - Perini G / 2002 / Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines / J Exp Med 195 : 907 ~ 918
[학술지(정기간행물)] - Giovannini MG / 2002 / Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway / Neurobiol Dis 11 : 257 ~ 274
[학술지(정기간행물)] - Ibach B / 2004 / Acetylcholinesterase inhibition in Alzheimer’s Disease / Curr Pharm Des 10 : 231 ~ 251
[학술지(정기간행물)] - Golde TE / 2006 / Disease modifying therapy for AD? / J Neurochem 99 : 689 ~ 707
[학술지(정기간행물)] - Perini G / 2002 / Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines / J Exp Med 195 : 907 ~ 918
[학술지(정기간행물)] - Giovannini MG / 2002 / Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway / Neurobiol Dis 11 : 257 ~ 274
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UCI(KEPA) : I410-ECN-0101-2018-524-001598294