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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 253 - 257 (5page)
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초록· 키워드
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Objective: To investigate and quantify functional deficit in ischemic stroke rat.
Method: Male Sprague-Dawley rats were divided into sham group and stroke group. Permanent cerebral ischemia was inflicted on the stroke group by occluding the middle cerebral artery (MCAO). The proportion of hind limb weight bearing pressure was also measured. The withdrawal threshold values in the hindpaws were measured by using von-Frey hair for seven days from the day before ischemia.Results: The proportion of paretic hind limb pressure to whole hind limb pressure in stroke group was significantly reduced than sham group (p＜0.05). The withdrawal threshold values of the paretic hindpaw in stroke group were not different from those in the sham group during whole experimental session (p＞0.05). Garcia motor score of stroke group was reduced significantly than sham group in whole experimental session after MCAO (p＜0.05). The proportions of right hind limb pressure showed no correlation with Garcia motor score after MCAO (p＞0.05).Conclusion: Ischemic stroke in rats can lead to the reduction of pressure at paretic hind limb. The motor test for pressure weight borne on the paretic leg may provide functional information in the future studies with ischemic stroke rat.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Ballermann M. / 2001 / The pasta matrix reaching task: a simple test for measuring skilled reaching distance, direction, and dexterity in rats / J Neurosci Methods 106 : 39 ~
Choi Y. B. / 2004 / Protective effect of epigallocatechin gallate on brain damage after transient middle cerebral artery occlusion in rats / Brain Res 1019 : 47 ~ 54
Chu K. / 2004 / Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia / Brain Res 1016 : 145 ~ 153
Ding Y. / 2002 / Impaired motor activity and motor learning function in rat with middle cerebral artery occlusion / Behav Brain Res 132 : 29 ~ 36
Garcia J. H. / 1995 / Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation / Stroke 26 : 627
Choi Y. B. / 2004 / Protective effect of epigallocatechin gallate on brain damage after transient middle cerebral artery occlusion in rats / Brain Res 1019 : 47 ~ 54
Chu K. / 2004 / Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia / Brain Res 1016 : 145 ~ 153
Ding Y. / 2002 / Impaired motor activity and motor learning function in rat with middle cerebral artery occlusion / Behav Brain Res 132 : 29 ~ 36
Garcia J. H. / 1995 / Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation / Stroke 26 : 627
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