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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 163 - 168 (6page)
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초록· 키워드
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Objective: The purpose of this study was to investigate the effect of ischemic stroke on bone metabolism.
Method: Female Sprague-Dawley rats (12 weeks old, n=48) were randomly divided into 4 separate groups; sham operation group (group A), stroke group (group B), ovariectomy group (group C), and stroke-ovariectomy group (group D). Two weeks after performing ovariectomy, cerebral ischemia was induced. The bone mineral density (BMD) and osteocalcin and carboxy-terminal telopeptide (CTX) were measured on three periods: the day before ischemia and 1 and 3 weeks post-stroke. All data were statistically analyzed.
Results: One week after cerebral ischemia, lumbar spine BMD of group B and D although statistically insignificant
showed a lower BMD score in comparison to group A and C, respectively. Three weeks after ischemia, compared to group C, the BMD score of lumbar spine in group D was reduced significantly (p＜0.05). At one week post-stroke, compared with group A and C, the value of osteocalcin in group B and D were reduced significantly, respectively (p＜0.05). One and three weeks after ischemia, the CTX value in all groups showed no statistical difference.
Conclusion: The authors concluded that ischemic stroke affected bone metabolism by decreasing osteoblastic activity in the early phase of stroke rat.
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