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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 530 - 537 (8page)
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초록· 키워드
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Background: Measurement of insulin and C-peptide concentrations is important for deciding whether insulin treatment is required in diabetic patients. We aimed to investigate the analytical performance of insulin and C-peptide assays using the Lumipulse G1200 system (Fujirebio Inc., Tokyo, Japan). Methods: We examined the precision, linearity, and cross-reactivity of insulin and C-peptide using five insulin analogues and purified proinsulin. A method comparison was conducted between the Lumipulse G1200 and Roche E170 (Roche Diagnostics, Mannheim, Germany) systems in 200 diabetic patients on insulin treatment. Reference intervals for insulin and C-peptide concentrations were determined in 279 healthy individuals. Results: For insulin and C-peptide assays, within-laboratory precision (% CV) was 3.78–4.14 and 2.89–3.35%, respectively. The linearity of the insulin assay in the range of 0–2,778 pmol/L was R²=0.9997, and that of the C-peptide assay in the range of 0–10 nmol/L was R²=0.9996. The correlation coefficient (r) between the Roche E170 and Lumipulse G1200 results was 0.943 (P<0.001) for insulin and 0.996 (P<0.001) for C-peptide. The mean differences in insulin and C-peptide between Lumipulse G1200 and the Roche E170 were 19.4 pmol/L and 0.2 nmol/L, respectively. None of the insulin analogues or proinsulin showed significant cross-reactivity with the Lumipulse G1200. Reference intervals of insulin and C-peptide were 7.64–70.14 pmol/L and 0.17–0.85 nmol/L, respectively. Conclusions: Insulin and C-peptide tests on the Lumipulse G1200 show adequate analytical performance and are expected to be acceptable for use in clinical areas.
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참고문헌 (6)
참고문헌 신청
김상용 / 2014 / It’s Still Not Too Late to Make a Change: Current Status of Glycemic Control in Korea / Diabetes and Metabolism Journal 38(3):194~196
송선옥 / 2016 / Epidemiology of Type 1 Diabetes Mellitus in Korea through an Investigation of the National Registration Project of Type 1 Diabetes for the Reimbursement of Glucometer Strips with Additional Analyses Using Claims Data / Diabetes and Metabolism Journal 40(1):35~45
American Diabetes Association / 2016 / Classification and diagnosis of diabetes / Diabetes Care 39(S1):S13~S22
Clark PM / 1999 / Assays for insulin, proinsulin(s) and C-peptide / Ann Clin Biochem 36(Pt 5):541~564
김세림 / 2013 / 재조합 인슐린 치료 중 발생한 혈중 인슐린농도의 비정상적 상승 증례에 대한 고찰 / Laboratory Medicine Online 3(1):56~59
송선옥 / 2016 / Epidemiology of Type 1 Diabetes Mellitus in Korea through an Investigation of the National Registration Project of Type 1 Diabetes for the Reimbursement of Glucometer Strips with Additional Analyses Using Claims Data / Diabetes and Metabolism Journal 40(1):35~45
American Diabetes Association / 2016 / Classification and diagnosis of diabetes / Diabetes Care 39(S1):S13~S22
Clark PM / 1999 / Assays for insulin, proinsulin(s) and C-peptide / Ann Clin Biochem 36(Pt 5):541~564
김세림 / 2013 / 재조합 인슐린 치료 중 발생한 혈중 인슐린농도의 비정상적 상승 증례에 대한 고찰 / Laboratory Medicine Online 3(1):56~59
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