지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Bone remodeling is a continuous process of skeletal renewal during which bone formation is tightly coupled to bone resorption. Mechanical loading is an important regulator of bone formation and resorption. In recent studies, neurotransmitters such as vasoactive intestinal peptide (VIP) were found to be present inside bone tissue and have been suggested to potentially regulate bone remodeling. In this study, our objective was to use a pre-established in vitro oscillatory fluid flow-induced shear stress mechanical loading system to quantify the effect of VIP on bone resorptive activity and investigate its combined effect with mechanical loading. VIP decreased osteoclastogenesis significantly decreased RANKL/OPG mRNA ration by approximately 90%. Combined VIP and mechanical loading further decreased RANKL/OPG ratio to approximately 95%. These results suggest that VIP present in bone tissue may synergistically act with mechanical loading to regulate bone remodeling via suppression of bone resorptive activities.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
C.H. Kim / 2006 / Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling / Bone 39 : 1043 ~ 1047
C.T. Rubin / 1984 / Regulation of bone formation by applied dynamic loads / J Bone Joint Surg Am 66 : 397 ~ 402
E.L. Hohmann / 1983 / Vasoactive intestinal peptide stimulates bone resorption via a cyclic aden- osine 3’,5’-monophosphate-dependent mechanism / Endocrinology 112 : 1233
F. Elefteriou / 2005 / Neuronal signaling and the regulation of bone remodeling / Cell Mol Life Sci 62 : 2339 ~ 2349
H. Takayanagi / 2005 / Inflammatory bone destruction and osteoimmu- nology / J Periodontal Res 40 : 287 ~ 293
C.T. Rubin / 1984 / Regulation of bone formation by applied dynamic loads / J Bone Joint Surg Am 66 : 397 ~ 402
E.L. Hohmann / 1983 / Vasoactive intestinal peptide stimulates bone resorption via a cyclic aden- osine 3’,5’-monophosphate-dependent mechanism / Endocrinology 112 : 1233
F. Elefteriou / 2005 / Neuronal signaling and the regulation of bone remodeling / Cell Mol Life Sci 62 : 2339 ~ 2349
H. Takayanagi / 2005 / Inflammatory bone destruction and osteoimmu- nology / J Periodontal Res 40 : 287 ~ 293
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Bone modeling, remodeling, and skeletal health in children and adolescents: mineral accrual, assessment and treatment
Annals of Pediatirc Endocrinology & Metabolism
2017 .01
-
골다공증 발생요인에 따른 골대사 생화학적 지표의 변동 고찰
대한물리치료학회지(JKPT)
2002 .01
-
골개형(Bone Remodelling)의 분자생물학적 기전에 대한 노화, 에스트로젠 및 산화적 스트레스의 영향
Toxicological Research
2006 .09
-
Bone defect model in animals for evaluation of bone grafts
한국실험동물학회 학술발표대회 논문집
2016 .02
-
전이성 골암으로 인한 골질 변화와 이로 인한 골절 위험성 분석
의공학회지
2012 .01
-
Evaluation of bone formation after grafting with cancellous and cortical bone allografts in the treatment of bone defects around implants
Oral Biology Research
2011 .01
-
SSP 주파수 진폭변조가 Vasoactive Intestinal Peptide와 $\beta$-endorphin, cGMP에 미치는 영향
대한물리치료학회지(JKPT)
2002 .01
-
갑상선자극호르몬이 골대사에 미치는 영향
International Journal of Thyroidology
2016 .01
-
양성 골종양의 수술적 치료 후 발생한 골결손에서 시행한 Hydroxyapatite의 조기 결과
대한골관절종양학회지
2008 .01
-
폐경 후 여성의 골량과 피부두겹두께 및 뇨 콜라겐펩타이드 양의 관련성에 대한 고찰
기초간호자연과학회지
2001 .01
-
A Simple Surgical Guide for Horizontal Bone Graft: A Technical Note
Journal of International Society for Simulation Surgery
2016 .01
-
Bone Remodeling과 Bone healing과의 임상적인 차이는 무엇입니까?
대한치과의사협회지
1996 .08
-
Application of Bonelike® as synthetic bone graft in orthopaedic and oral surgery in veterinary clinical cases.
생체재료학회지
2019 .01
-
소아의 골밀도에 관한 연구
대한한방소아과학회지
2005 .01
-
Pre-clinical test platform for the evaluation of bone scaffolds using several animal models in DGMIF-LAC
한국실험동물학회 학술발표대회 논문집
2016 .08
-
기능별 뼈이식재의 임프란트 적용방법
대한치과의사협회지
2010 .04
-
한국인 연령에 따른 하악 치조골 골밀도
대한구강악안면외과학회지
2011 .01
-
생선가시의 전산화 단층촬영 자료에 삼차원 재구성법을 적용한 연구
대한기관식도과학회지
2012 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0