지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
While much has been learned about the mechanisms of metastatic spread of cancer to bone, there has been little headway in establishing guidelines for monitoring the alteration in bone quality and estimating fracture risk. The aims of this study are, therefore, 1) to evaluate bone quality induced by metastatic bone tumor by analyzing the characteristics on bone microarchitecture and degree of bone mineralization and 2) analyze fracture risk increased secondary to the bone quality changes by metastatic bone tumor through calculating mechanical rigidities based on in-vivo micro CT images. For this study, eighteen female SD rats (12 weeks old, approximate 250 g) were randomly allocated in Sham and Tumor groups. W256 (Walker carcinosarcoma 256 malignant breast cancer cell) was inoculated in the right femur (intraosseous injection) in Tumor group, while 0.9% NaCl (saline solution) was injected in Sham group. The right hind limbs of all rats were scanned by in-vivo micro-CT to acquire structural parameters and degree of bone mineralization at 0 week, 4 weeks, 8 weeks, and 12 weeks after surgery. At the same time, urine was collected by metabolic cages for a biochemical marker test in order to evaluate bone resorption. Then, bone metastasis had been directly identified by positron emission tomography. Finally, axial, bending and torsional rigidities had been calculated based on in-vivo micro CT images for predict fracture risk. The results of this study showed that metastatic bone tumor might induce significant decrease in bone quality and increase of fracture risk. This study may be helpful to monitoring a degree of bone metastasis and predicting fracture risk due to metastatic bone tumor. In addition, this noninvasive diagnostic methodology may be utilized for evaluating other bone metabolic diseases such as osteoporosis.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
A.A. Kurth / 2001 / The effect of an osteolytic tumor on the three-dimensional trabecular bone morphology in an animal model / Skeletal Radiol 30 (2) : 94 ~ 98
A.A. Kurth / 2007 / Preventative ibandronate treatment has the most beneficial effect on the microstructure of bone in experimental tumor osteolysis / J Bone Miner Meta 25 (
B.D. Snyder / 2006 / Predicting fracture through benign skeletal lesions with quantitative computed tomography / J Bone Joint Surg Am 88 (1) : 55 ~ 70
C.M Deroose / 2007 / Multimodality imaging of tumor xenografts and metastases in mice with combined small-animal PET, small-animal CT, and bioluminescence imaging / J Nucl M
D. Heymann / 2009 / Bone Cancer / Academic Press : 3 ~ 4
A.A. Kurth / 2007 / Preventative ibandronate treatment has the most beneficial effect on the microstructure of bone in experimental tumor osteolysis / J Bone Miner Meta 25 (
B.D. Snyder / 2006 / Predicting fracture through benign skeletal lesions with quantitative computed tomography / J Bone Joint Surg Am 88 (1) : 55 ~ 70
C.M Deroose / 2007 / Multimodality imaging of tumor xenografts and metastases in mice with combined small-animal PET, small-animal CT, and bioluminescence imaging / J Nucl M
D. Heymann / 2009 / Bone Cancer / Academic Press : 3 ~ 4
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