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자료유형
학술저널
저자정보
저널정보
대한재활의학회 Annals of Rehabilitation Medicine Annals of Rehabilitation Medicine 제29권 제2호
발행연도
2005.1
수록면
187 - 192 (6page)

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Objective: The aim of this study was to investigate the changes of bone mineral density (BMD) according to the postinjury duration, walking ability, and to assess the effect of oral alendronate therapy on BMD and biochemical markers in patients with spinal cord injury. Method: Forty-eight subjects with spinal cord injury were enrolled. One tablet of AlendⓇ (10 mg of sodium alendronate) was administered daily for 6 months. After this, all subjects received placebo for 6 months as the same manner. The baseline quantitative assessments of BMD and biochemical bone markers, serum osteocalcin and C-terminal telopeptide of type I collagen (ICTP), were performed before the administration of drug. The follow up assess-ments were performed at 6 and 12 months after drug and placebo administration. Results: The patients treated with oral alendronate showed significantly higher BMD of femur compared with baseline (p<0.05). Also, ICTP showed significant reduction after alendronate therapy. BMD change rate of alendronate therapy was higher in functional ambulation group compared with wheelchair ambulation group. BMD change rate of alendronate therapy was higher than that of placebo administration. Conclusion: Alendronate therapy may be useful in prevention of loss of BMD after spinal cord injury.

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