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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 466 - 472 (7page)
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초록· 키워드
오류제보하기
Background: Following discontinuation of the recombinant immunoblot assay (RIBA), the only available supplementary test for the detection of hepatitis C virus (HCV) is the nucleic acid amplification test (NAAT). However, the NAAT does not adequately detect past HCV. Consequently, it is hard to distinguish between past HCV infection and biological false positivity with an anti-HCV result alone. We assessed the diagnostic performance of two immunoassays: the ARCHITECT anti-HCV chemiluminescent microparticle immunoassay (CMIA; Abbott Diagnostics, Wiesbaden, Germany) and the Access HCV Ab PLUS chemiluminescent immunoassay (CIA; Bio-Rad, Marnes-la-Coquette, France). We also explored an optimized algorithm to determine the anti-HCV results. Methods: We tested 126,919 patients and 44,556 individuals who underwent a medical checkup. RIBA and NAAT were conducted for samples that tested anti-HCV-positive using CMIA and CIA. We assessed the optimal signal-to-cutoff (S/CO) ratio in HCV-positive samples. Results: In total, 1,035 blood samples tested anti-HCV-positive. Of these, RIBA was positive in 512, indeterminate in 160, and negative in 363 samples. One hundred sixty-five samples were NAAT-positive. Diagnostic sensitivity and positive predictive value (PPV) were 96.7% and 52.1%, respectively, for CMIA, and 94.7% and 72.3%, respectively, for CIA. The optimal S/CO ratio was 5.2 for CMIA and 2.6 for CIA at 95% PPV. In total, 286 samples tested positive in CMIA and 444 in CIA, while 443 samples tested positive in both assays. Conclusions: It is hard to determine anti-HCV positivity based on the S/CO ratio alone. However, this study elucidated the role of the S/CO ratio by using the NAAT and RIBA.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Aldamiz-Echevarria L / 2012 / Asymmetric dimethylarginine, endothelial dysfunction and renal disease / Int J Mol Sci 13:11288~11311
Liu X / 2016 / Effect of asymmetric dimethlarginine (ADMA) on heart failure development / Nitric Oxide 54:73~81
Tain YL / 2017 / Toxic dimethylarginines: asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) / Toxins (Basel) 9:E92
McCarty MF / 2016 / Asymmetric dimethylarginine is a well-established mediating risk factor for cardiovascular morbidity and mortality-should patients with elevated levels be supplemented with citrulline? / Healthcare (Basel) 4:E40
Erbil MK / 2012 / Metabolism of asymmetric dimethylarginine and its clinical significance / Turk J Bioch 37:99~105
Liu X / 2016 / Effect of asymmetric dimethlarginine (ADMA) on heart failure development / Nitric Oxide 54:73~81
Tain YL / 2017 / Toxic dimethylarginines: asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) / Toxins (Basel) 9:E92
McCarty MF / 2016 / Asymmetric dimethylarginine is a well-established mediating risk factor for cardiovascular morbidity and mortality-should patients with elevated levels be supplemented with citrulline? / Healthcare (Basel) 4:E40
Erbil MK / 2012 / Metabolism of asymmetric dimethylarginine and its clinical significance / Turk J Bioch 37:99~105
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