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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 475 - 480 (6page)
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초록· 키워드
오류제보하기
Background: Intrachromosomal amplification of chromosome 21 (iAMP21) is known to be associated with poor prognosis in B-cell ALL (B-ALL). To determine the frequency and clinical characteristics of iAMP21 in Korean B-ALL patients, we performed FISH and multiplex ligation-dependent probe amplification (MLPA) analyses.
Methods: A total of 102 childhood B-ALL patients were screened with ETV6-RUNX1 FISH probes (Abbott Molecular, USA). The presence of an iAMP21 was confirmed by using MLPA P327 iAMP21-ERG probemix (MRC Holland, The Netherlands).
Results: iAMP21 was detected in one of the screened B-ALL patients (1/102 patients, 1.0%) who presented the ALL immunophenotype and complex karyotype at initial diagnosis. The patient relapsed twice after bone marrow transplantation. MLPA showed 12.5-Mb and 4.28-Mb regions of amplification and deletion, respectively.
Conclusions: The frequency of iAMP21 is considerable in Korean pediatric patients. Our report suggests that iAMP21 in childhood B-ALL has very unfavorable impact on patient’s prognosis. Additional methods such as MLPA analysis is essential to rule out patients with equivocal interphase FISH results.
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등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Pui C-H / 2012 / Childhood leukemias / Cambridge University Press :880S
Harewood L / 2003 / Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases / Leukemia 17:547~553
Harrison CJ / 2005 / Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group Study / Br J Haematol 129:520~530
Harrison CJ / 2010 / Detection of prognostically relevant genetic abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: recommendations from the Biology and Diagnosis Committee of the International Berlin-Frankfürt-Münster study group / Br J Haematol 151:132~142
Reichard KK / 2011 / Pediatric B-lymphoblastic leukemia with RUNX1 amplification: clinicopathologic study of eight cases / Mod Pathol 24:1606~1611
Harewood L / 2003 / Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases / Leukemia 17:547~553
Harrison CJ / 2005 / Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group Study / Br J Haematol 129:520~530
Harrison CJ / 2010 / Detection of prognostically relevant genetic abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: recommendations from the Biology and Diagnosis Committee of the International Berlin-Frankfürt-Münster study group / Br J Haematol 151:132~142
Reichard KK / 2011 / Pediatric B-lymphoblastic leukemia with RUNX1 amplification: clinicopathologic study of eight cases / Mod Pathol 24:1606~1611
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