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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 364 - 372 (9page)
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Background : We utilized results from the ARTEMIS DISK Global Antifungal Surveillance Program to evaluate the species distribution and fluconazole and voriconazole susceptibilities of yeast isolates from clinical specimens in South Korea from 2001 to 2007.
Methods : Data were collected on 5,665 yeast isolates from all body sites at three locations. All investigators tested clinical yeast isolates using the CLSI M44-A disk diffusion method. Test plates were automatically read and results were recorded using the BIOMIC image analysis plate reader system (Giles Scientific, USA). Species, drug, zone diameter, susceptibility category, and quality control results were collected quarterly via e-mail for analysis.
Results: Candida albicans was the most common isolate, but a progressive increase in non-C. albicans Candida and noncandidal yeast species has been observed in recent years. The overall percentages of isolates in each category (susceptible, susceptible dose dependent, and resistant)were 98.8%, 0.5%, and 0.7% and 99.2%, 0.2%, and 0.6% for fluconazole and voriconazole, respectively. Candida of 3 species exhibited decreased susceptibility to fluconazole (<90% S) in the order of that seen with the resistant (R) species: C. krusei, C. guilliermondii, and C. glabrata.
Emerging resistance to fluconazole or voriconazole was documented among isolates of Cryptococcus neoformans, Trichosporon spp., and Rhodotorula spp.
Conclusions : The species distribution and antifungal susceptibilities of yeasts may differ according to specimen type, testing method, hospital, and geographic region. Therefore, further largescaled, long-term surveillance studies are needed to isolate yeasts and to confirm the species distribution and antifungal susceptibilities of yeast isolates from clinical specimens in Korea. (Korean J Lab Med 2010;30:364-72)
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참고문헌 (19)
참고문헌 신청
Hazen KC / 2003 / Comparison of the susceptibilities of Candida spp. to fluconazole and voriconazole in a 4-yr global evaluation using disk diffusion / J Clin Microbiol 41 :
Isenberg HD / 2003 / Clinical microbiology procedures handbook. 2nd ed / ASM Press
Kim SH / 2009 / The relationship between antifungal usage and antifungal susceptibility in clinical isolates of Candida: a multicenter Korean study / Med Mycol 4 : 296 ~ 304
Lee MK / 2007 / Susceptibility and trailing growth of Candida albicans to fluconazole:results of a Korean multicentre study / Mycoses 50 : 148 ~ 149
Pfaller MA / 2004 / Comparison of results of fluconazole disk diffusion testing for Candida species with results from a central reference laboratory in the ARTEMIS global an
Isenberg HD / 2003 / Clinical microbiology procedures handbook. 2nd ed / ASM Press
Kim SH / 2009 / The relationship between antifungal usage and antifungal susceptibility in clinical isolates of Candida: a multicenter Korean study / Med Mycol 4 : 296 ~ 304
Lee MK / 2007 / Susceptibility and trailing growth of Candida albicans to fluconazole:results of a Korean multicentre study / Mycoses 50 : 148 ~ 149
Pfaller MA / 2004 / Comparison of results of fluconazole disk diffusion testing for Candida species with results from a central reference laboratory in the ARTEMIS global an
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