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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 185 - 189 (5page)
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초록· 키워드
오류제보하기
To date, the determination of serum vitamin B12 levels has been the most common laboratory test for the assessment of vitamin B12 status; however, the diagnostic accuracy of this test is low. To obtain a more sensitive marker, a new test to measure holotranscobalamin (holoTC) levels has been introduced. In this study, we assessed 45 patients for whom a vitamin B12 test had been requested and 139 anemic patients. We investigated the associations between the levels of homocysteine (Hcy) and those of holoTC, serum vitamin B12, and folate and assessed the diagnostic value of holoTC levels as a marker for vitamin B12 deficiency. We also determined the precision of the AxSYM holoTC assay by calculating the coefficient of variance (CV). The within-run and betweenrun precision values were excellent, as all CV values were less than 3.5%. The holoTC levels were low (<35 pmol/L) in 7 samples, and 6 of these samples had normal total serum vitamin B12 levels. In 2 of these samples, high Hcy levels (>12 mmol/L) indicated vitamin B12 deficiency. Thus, the holoTC levels were more sensitive than the serum vitamin B12 levels for indicating vitamin B12 status.
If the serum vitamin B12 level is 151-300 pmol/L, the levels of holoTC alone or in combination with serum vitamin B12 levels are likely to be more useful markers than serum vitamin B12 levels alone. (Korean J Lab Med 2010;30:185-9)
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Allen LH / 1995 / Vitamin B-12 deficiency and malabsorption are highly prevalent in rural Mexican communities / Am J Clin Nutr 62 : 1013 ~ 1019
Bolann BJ / 2000 / Evaluation of indicators of cobalamin deficiency defined as cobalamin-induced reduct
Brady J / 2008 / Active B12: a rapid, automated assay for holotranscobalamin on the Abbott Ax-SYM analyzer / Clin Chem 54 : 567 ~ 573
Devalia V / 2006 / Diagnosing vitamin B-12 deficiency on the basis of serum B-12 assay / BMJ 333 : 385 ~ 386
Fakhrzadeh H / 2006 / Total plasma homocysteine, folate, and vitamin B12 status in healthy Iranian adults: the Tehran homocysteine survey (2003-2004)/a cross-sectional popul
Bolann BJ / 2000 / Evaluation of indicators of cobalamin deficiency defined as cobalamin-induced reduct
Brady J / 2008 / Active B12: a rapid, automated assay for holotranscobalamin on the Abbott Ax-SYM analyzer / Clin Chem 54 : 567 ~ 573
Devalia V / 2006 / Diagnosing vitamin B-12 deficiency on the basis of serum B-12 assay / BMJ 333 : 385 ~ 386
Fakhrzadeh H / 2006 / Total plasma homocysteine, folate, and vitamin B12 status in healthy Iranian adults: the Tehran homocysteine survey (2003-2004)/a cross-sectional popul
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