지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 301 - 306 (6page)
이용수
초록· 키워드
오류제보하기
Background : Inflammatory cytokines such as tumor necrosis factor alpha (TNFa) and interleukin (IL)-6 play an important role in pathophysiology of rheumatoid arthritis (RA). We investigated the possibility whether TNFa and IL-6 could be used as an objective marker reflecting treatment response in RA.
Methods : Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and rheumatoid factor (RF) together with TNFa and IL-6 were measured in 159 specimens obtained from 95 RA patients. RA patients were divided into pre-treatment, methotrexate (MTX) and non-MTX groups by treatment regimen and into inactive and active groups by disease activity. The agreement between changes in marker levels and treatment response, and the correlation between each marker were analyzed.
Results : IL-6 was higher in active than in inactive group of patients in all three different treatment subgroups, but TNFa was not different between the two groups. IL-6 showed a better agreement with treatment response (MTX group, K=0.58; non-MTX group, K=0.21) than ESR or CRP, whereas TNFa did not show an agreement with treatment response. IL-6 was correlated with both ESR (r=0.22) and CRP (r=0.54), but TNFa was correlated only with ESR (r=0.21).
Conclusions : Unlike TNFa, IL-6 reflects disease activity of RA and shows a better agreement with treatment response than ESR or CRP, indicating that it has an association with clinical features of RA. Therefore IL-6 could be used as an additional marker in the evaluation of treatment response when markers like ESR or CRP show results discordant from clinical features. (Korean J Lab Med 2010;30:301-6)
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Barrera P / 1993 / Circulating soluble tumor necrosis factor receptors, interleukin-2 receptors, tumor necrosis factor alpha, and interleukin-6 levels in rheumatoid arthriti
Barrera P / 1995 / Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating concentrations of cytokines and their antagonists. Lo
Brennan FM / 2008 / Evidence that cytokines play a role in rheumatoid arthritis / J Clin Invest 118 : 3537 ~ 3545
Cronstein BN / 2007 / Interleukin-6--a key mediator of systemic and local symptoms in rheumatoid arthritis / Bull NYU Hosp Jt Dis 65 (Suppl 1) : S11 ~ S5
Dasgupta B / 1992 / Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis / J Rheumatol 19 : 22 ~ 25
Barrera P / 1995 / Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating concentrations of cytokines and their antagonists. Lo
Brennan FM / 2008 / Evidence that cytokines play a role in rheumatoid arthritis / J Clin Invest 118 : 3537 ~ 3545
Cronstein BN / 2007 / Interleukin-6--a key mediator of systemic and local symptoms in rheumatoid arthritis / Bull NYU Hosp Jt Dis 65 (Suppl 1) : S11 ~ S5
Dasgupta B / 1992 / Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis / J Rheumatol 19 : 22 ~ 25
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Elevated Levels of T Helper 17 Cells Are Associated with Disease Activity in Patients with Rheumatoid Arthritis
Annals of Laboratory Medicine
2013 .01
-
The Correlation between Increased Serum Concentrations of Interleukin-6 Family Cytokines and Disease Activity in Rheumatoid Arthritis Patients
Yonsei Medical Journal
2011 .01
-
Correlation between Cytokine and Chemokine levels and Clinical Severity in Children with Mycoplasma pneumoniae Pneumonia
Pediatric Infection and Vaccine
2019 .01
-
침 치료가 류머티즘성 관절염 환자의 혈액학적 지표 및 혈장 내 사이토카인에 미치는 영향
Korean Journal of Acupuncture
2009 .01
-
Wheel Balanced Cancer Therapy for Longer Than 21 Days Can Have a Positive Effect on the Survival of Patients with Stage IV Cancer
Journal of Pharmacopuncture
2015 .01
-
류마티스관절염 환자의 활액 세포에서 IL-17과 IL-1β에 의한 IL-23p19의 발현 증가
Immune Network
2008 .03
-
Regulatory B Cells Are Inversely Associated with Disease Activity in Rheumatoid Arthritis
Yonsei Medical Journal
2014 .01
-
High Throughput Fluorogenic Assay for TNF-alpha Converting Enzyme(TACE) inhibitors
대한약학회 학술대회
2003 .01
-
인공고관절 치환술 전후의 CRP 및 ESR의 변화
영남의대학술지
1992 .01
-
Influence of Infliximab on Cytokines Network and Markers of Bone Remodeling in Rheumatoid Arthritis Patients
Yonsei Medical Journal
2013 .01
-
Th17과 자가면역 관절염
Immune Network
2007 .03
-
The Serum Levels of Resistin and Its Relationship with Other Proinflammatory Cytokines in Patients with Alzheimer’s Disease
Clinical Psychopharmacology and Neuroscience
2017 .01
-
류마티스성 관절염 환자에서의 청력감소
대한이비인후-두경부외과학회지
2009 .01
-
당뇨발 감염진단을 위한 WBC, ESR, CRP의 유용성 비교
대한성형외과학회지
2010 .01
-
C-reactive Protein and Erythrocyte Sedimentation Rate Discrepancies and Variations after Intravenous Immunoglobulin Therapy in Kawasaki Disease
Pediatric Infection and Vaccine
2016 .01
-
The Allele 2 of the VNTR Polymorphism in the Gene That Encodes a Natural Inhibitor of IL-1β, IL-1RA Is Favorably Associated With Chronic Otitis Media
Clinical and Experimental Otorhinolaryngology
2018 .01
-
Upregulation of ESR1 Gene and ESR Ratio(ESR1/ESR2) are Associated with Worse Prognosis in Papillary Thyroid Carcinoma
대한외과학회 학술대회 초록집
2016 .11
-
Plasma Levels of IL-23 and IL-17 before and after Antidepressant Treatment in Patients with Major Depressive Disorder
PSYCHIATRY INVESTIGATION
2013 .01
-
TNF-$\alpha$ and TNF-$\beta$ polymorphisms with susceptibility to gastric cancer in a Korean population
Molecular & cellular toxicology
2010 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0