지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 312 - 318 (7page)
이용수
초록· 키워드
오류제보하기
Background : We evaluated the performance and false positive rate of Mediace RPR test (Sekisui, Japan), a newly introduced nontreponemal test using a chemistry autoanalyzer.
Methods : The sensitivity of Mediace RPR test was analyzed using sera from 50 patients with syphilis in different stages (8 primary, 7 secondary, and 35 latent), 14 sera positive with fluorescent treponemal antibody absorption (FTA-ABS) IgM, and 74 sera positive with conventional rapid plasma regain
(RPR) card test (Asan, Korea) and also positive with Treponema pallidum hemagglutination (TPHA) test or FTA-ABS IgG test. The specificity was analyzed on 108 healthy blood donors. We also performed RPR card test on 302 sera that had been tested positive with Mediace RPR test and also
performed TPHA or FTA-ABS IgG test to analyze the false positive rate of Mediace RPR test. A cutoff value of 0.5 R.U. (RPR unit) was used for Mediace RPR test.
Results : Mediace RPR test on syphilitic sera of different stages (primary, secondary, and latent stages) and FTA-ABS IgM positive sera showed a sensitivity of 100%, 100%, 82.9% and 100%, respectively. Among the 74 sera positive with conventional RPR card test and TPHA or FTA-ABS
IgG test, 55 were positive with Mediace test. The specificity of Mediace RPR test on blood donors was 97.2%. Among the 302 sera positive with Mediace RPR test, 137 sera (45.4%) were negative by RPR card and TPHA/FTA-ABS IgG tests.
Conclusions : Although the sensitivities of Mediace RPR were good for primary and secondary syphilis, due to its high negative rate of Mediace RPR over the conventional RPR positive samples, further studies are necessary whether it can replace conventional nontreponemal test for screening
purpose. Moreover, in view of the high false positive rate, positive results by Mediace RPR test should be confirmed with treponemal tests. (Korean J Lab Med 2008;28:312-8)
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Centers for Disease Control and Prevention / 1997 / Case definitions for infectious conditions under public health surveillance / MMWR Recomm Rep 46 (RR-10) : 1 ~ 55
Centers for Disease Control and Prevention / 2006 / Sexually transmitted diseases treatment guidelines / MMWR Recomm Rep 55 (RR-11) : 1 ~ 94
Kawai K / 2003 / The possibility of assessing the stage of infection by using Sekisui’s automated TPLA and RPR / J Clin Lab Instrum Reag 26 : 301 ~ 304
Kinjyo T / 2005 / Laboratory-based evaluation of latex-agglutination turbidemetric assay by Mediace RPR on P Module of Hitachi autoanalyzer 7600 to quantitatively determine s
Kume T. / 2003 / The clinical utility of quantitation for anti-lipoidal antibody in serum using a latex agglutination immunoassay on an automatic analyzer / Jap J Clin Lab As
Centers for Disease Control and Prevention / 2006 / Sexually transmitted diseases treatment guidelines / MMWR Recomm Rep 55 (RR-11) : 1 ~ 94
Kawai K / 2003 / The possibility of assessing the stage of infection by using Sekisui’s automated TPLA and RPR / J Clin Lab Instrum Reag 26 : 301 ~ 304
Kinjyo T / 2005 / Laboratory-based evaluation of latex-agglutination turbidemetric assay by Mediace RPR on P Module of Hitachi autoanalyzer 7600 to quantitatively determine s
Kume T. / 2003 / The clinical utility of quantitation for anti-lipoidal antibody in serum using a latex agglutination immunoassay on an automatic analyzer / Jap J Clin Lab As
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