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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 768 - 775 (8page)
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초록· 키워드
오류제보하기
Background: Automated analyzer-based nontreponemal serological tests for syphilis (STS) have been used for several decades. Objective: In this study, we evaluated serological responses to treatment and proposed clinical guidelines for automated STS. Methods: This retrospective cohort study analyzed human immunodeficiency virus-negative syphilis patients who were diagnosed with automated rapid plasma reagin (auto RPR) tests as a nontreponemal STS, and who also received the fluorescent treponemal antibody-absorption test as a confirmatory test. The ratio of auto RPR values after treatment against those at baseline was defined as the auto RPR ratio for the analysis of the serological response to treatment. The cutoff value for reliable seroreversion prediction was assessed with receiver-operating-characteristic curves. Results: Overall, 89.7% of participants (78/87) seroreverted and 10.3% of participants (9/87) remained serofast during the two-year follow-up period. We were unable to describe trends in the changes among auto RPR values within six months after treatment because of high variation. All of the patients who had an auto RPR ratio ≥1.0 after six months continuously had positive serologic results during their 24-month follow-up and were classified as a serofast group.
The receiver-operating-characteristic curves revealed a 25% reduction in auto RPR values nine months after treatment and predicted seroreversion with a sensitivity of 96.2% and a specificity of 100%. Conclusion: The most important primary checkpoint for syphilis treatment response is an increase in automated nontreponemal STS six months after treatment.
Thus, we recommend monitoring the treatment response with an auto RPR.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Brown ST / 1985 / Serological response to syphilis treatment. A new analysis of old data / JAMA 253 : 1296 ~ 1299
Centers for Disease Control and Prevention / 1997 / Case definitions for infectious conditions under public health surveillance / MMWR Recomm Rep 46 : 1 ~ 55
Choi SJ / 2013 / Comparisons of fully automated syphilis tests with conventional VDRL and FTA-ABS tests / Clin Biochem 46 : 834 ~ 837
Holman KM / 2012 / Rapid plasma reagin titer variation in the 2weeks after syphilis therapy / Sex Transm Dis 39 : 645 ~ 647
Janier M / 2014 / European guideline on the management of syphilis / J Eur Acad Dermatol Venereol 28 : 1581 ~ 1593
Centers for Disease Control and Prevention / 1997 / Case definitions for infectious conditions under public health surveillance / MMWR Recomm Rep 46 : 1 ~ 55
Choi SJ / 2013 / Comparisons of fully automated syphilis tests with conventional VDRL and FTA-ABS tests / Clin Biochem 46 : 834 ~ 837
Holman KM / 2012 / Rapid plasma reagin titer variation in the 2weeks after syphilis therapy / Sex Transm Dis 39 : 645 ~ 647
Janier M / 2014 / European guideline on the management of syphilis / J Eur Acad Dermatol Venereol 28 : 1581 ~ 1593
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