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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 174 - 178 (5page)
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초록· 키워드
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Trisomy 19 is frequently encountered in cases of chronic myeloid leukemia (CML) as a secondary
abnormality: however, trisomy 19 rarely occurs as a sole chromosomal abnormality and, to date, it
has only been reported in 48 hematopoietic malignancies, 1 case of adenocarcinoma and 1 case
of astrocytic tumor. Here, we report two additional cases of trisomy 19 as a sole karyotypic aberration
in myeloid malignancies. One of these cases involved a 6-month-old male who was diagnosed
with acute myeloid leukemia minimally differentiated. His karyotype was 47,XY,+19[20]. He expired
5 days after diagnosis. Another case occurred in an 80-yr-old female who had refractory anemia
with excess blasts. Her karyotype was 47,XX,+19[16]/46,XX[4]. Four months later, her peripheral
blood smears suggested that the disease had progressed, but she refused further evaluation. Based
on a review of the existing literature and the results of this report, trisomy 19 not only as a secondary
abnormality but also as a sole karyotypic aberration is strongly associated with myeloid disorder;
however, it is not preferentially found in specific FAB subgroups of myelodysplasic syndrome or
acute myeloid leukemia. (Korean J Lab Med 2008;28:174-8)
목차
등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
/ 1992 / Primary, single, autosomal trisomies associated with haematological disorders. United Kingdom Cancer Cytogenetics Group (UKCCG). Leuk Res 1992;16:841-51
Babic I / 2007 / Prenatal diagnosis of complete trisomy 19q / Prenat Diagn 27 : 644 ~ 647
Daskalakis M / 2002 / Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2’-deoxycytidine(decitabine) treatment / Blood 10
Daskalakis M / 2006 / Trisomy 19 as the sole chromosome abnormality in proliferative chronic myelomonocytic leukemia / Leuk Res 30 : 1043 ~ 1047
Diez-Martin JL / 1988 / Possible cytogenetic distinction between lymphoid and myeloid blast crisis in chronic granulocytic leukemia / Am J Hematol 27 : 194 ~ 203
Babic I / 2007 / Prenatal diagnosis of complete trisomy 19q / Prenat Diagn 27 : 644 ~ 647
Daskalakis M / 2002 / Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2’-deoxycytidine(decitabine) treatment / Blood 10
Daskalakis M / 2006 / Trisomy 19 as the sole chromosome abnormality in proliferative chronic myelomonocytic leukemia / Leuk Res 30 : 1043 ~ 1047
Diez-Martin JL / 1988 / Possible cytogenetic distinction between lymphoid and myeloid blast crisis in chronic granulocytic leukemia / Am J Hematol 27 : 194 ~ 203
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