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논문 기본 정보

자료유형
학술저널
저자정보
Makis, William (Department of Nuclear Medicine, Brandon Regional Health Centre) Rakheja, Rajan (Department of Nuclear Medicine, Royal Victoria Hospital, McGill University Health Centre) Lavoie, Josee (Department of Pathology, Montreal Children's Hospital, McGill University Health Centre) Hickeson, Marc (Department of Nuclear Medicine, Royal Victoria Hospital, McGill University Health Centre)
저널정보
대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제46권 제2호
발행연도
2012.1
수록면
119 - 124 (6page)

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Tetrasomy 8 is a relatively rare chromosomal abnormality that has been reported in only 33 cases in hematologic disorders. It is known for its association with aggressive acute myeloid leukemia (AML) and myeloid sarcoma and is considered a very poor prognostic factor. Myeloid sarcoma is a rare hematologic malignancy characterized by tumor masses consisting of immature myeloid cells, presenting at an extramedullary site. We present a case of a 17-year-old boy referred for an $^{18}F$-FDG PET/CT for the evaluation of pleural masses and spinal bone lesions seen on CT, after presenting with a 4 month history of chest pain. The PET/CT revealed extensive FDG-avid extramedullary disease in the soft tissues of the chest, abdomen, and pelvis, which were biopsy-proven to be myeloid sarcoma, as well as extensive intramedullary disease biopsy proven to be AML. This is the first report of the use of $^{18}F$-FDG PET/CT to stage a subset of aggressive AML and myeloid sarcoma in a patient with an associated chromosomal abnormality (tetrasomy 8).

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