배경 : 우리나라는 B형 간염 유행지역으로 이에 대한 연구는 많이 있으나 A, C, D, E형 간염에 대한 전반적인 보고가 없는 실정이다. 이에 저자들은 A, B, C, D, E형 간염 바이러스의 혈
청학적 표지자를 조사하여 바이러스성 간염 항원, 항체의 혈청 양성률을 알아보고, 두 가지 이상의 바이러스에 중복 감염된 간염환자의 현황도 알아보고자 하였다.
방법 : 고려대학교 의과대학 3개 의료센터에 2003년 1월부터 12월까지 의뢰된 260,488검체를 대상으로 10종의 바이러스 항원항체 검사(anti-HAV IgM, anti-HAV IgG, HBsAg, anti-HBs, anti-HBc, anti-HBe, HBeAg, anti-HCV, anti-HDV, anti-HEV IgM)를 분석하였다.
결과 : Anti-HAV IgM과 IgG의 양성률은 각각 1.2%, 88.0%이었고, 20대 그룹에서 anti-HAV IgM 양성률이 높았다. HBsAg의 전체 양성률은 10.4%이고 anti-HBs는 60.4%이었다. Anti-
HCV 양성률은 1.3%, anti-HDV 양성률은 1.1%이고 anti-HEVIgM의 양성률은 22.2%이었다. HBsAg과 anti-HBs의 동시 양성 률은 4.0%이었다. Anti-HCV와 HBsAg 동시 양성인 경우는
HBsAg 양성자 중 7명(0.1%)이었으며, anti-HAV IgM와 anti-HEV IgM 동시 양성인 경우는 anti-HEV IgM 양성자 중 2명(25%)이었다.
결론 : 이 조사에서 A형 간염은 소아에서 감염이 현저히 낮았고 20대에 이환되는 경우가 많았다. A형 간염 환자에서 E형 간염도 양성인 경우가 많아 A형 간염이 의심될 경우 E형 간염 검
사도 고려되어야 한다고 생각된다. B형과 C형 간염의 중복 감염도 드물지만 관찰되고 있으므로 만성 간질환자의 경우에는 특히
다른 간염과의 중복감염을 확인하여야 할 것으로 생각된다.
Background : As an endemic area of viral hepatitis B, many studies on hepatitis B and C have been reported in Korea, but no on all five viral types, A, B, C, D, and E. We surveyed ten serologic markers for the five different viral hepatitis and reviewed the seropositivity of each viral hepatitis and concurrent infection. Methods : Ten serologic markers of five viral hepatitis (anti-HAV IgM, anti-HAV IgG, HBsAg, anti- HBs, anti-HBc, HBeAg, anti-HBe, anti-HCV, anti- HDV, and anti-HEV IgM) were tested for 260,488 samples requested for viral marker studies at three hospitals of Korea University Medical Centers from January through December, 2003. Anti-HAV IgM, anti-HAV IgG, anti-HDV, and anti-HEV IgM were tested by RIA and HBsAg, anti-HBs, anti- HBc, HBeAg, anti-HBe, and anti-HCV were analysed by ELISA or RIA method. Results : Anti-HAV IgM and IgG seropositivity was 1.2% and 88.0%, respectively. Anti-HAV IgM seropositivity was high in a patient group 20 to 29 years of age. The overall seropositivity of HBsAg was 10.4% and for anti-HBs 60.4%. The seropositivity was 1.3% for anti-HCV, 1.1% for anti-HDV, and 22.2% for anti- HEV IgM. The concurrent positivity of HBsAg and anti-HBs was 4.0%. HBsAg was positive in 7 (0.1%) of anti-HCV positive patients; anti-HEV IgM was positive in 2 (25%) of anti- HAV IgM positive patients. Conclusions : Hepatitis A infection was rare in children but increased in patient group 20 to 29 years of age. The concurrent infection rate of hepatitis A with hepatitis E was high, suggesting that hepatitis E should be considered in hepatitis A patients. In view of the finding that the concurrent infection of hepatis B and C was detected, though at a relatively low rate, patients with viral hepatitis need to be assessed for the possibility of concurrent infection with other types of hepatitis.