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초록· 키워드
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Neuron-on-a-Chip technology is based on advanced neuronal culture technique, surface micropatterning, microelectrode array technology, and multi-dimensional data analysis techniques. The combination of these techniques allowed us to design and analyze live biological neural networks in vitro using real neurons. In this review article, two underlying technologies are reviewed: Microelectrode array technology and Neuronal patterning technology. There are new opportunities in the fusion of these technologies to apply them in neurobiology, neuroscience, neural prostheses, and cell-based biosensor areas.
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참고문헌 (24)
참고문헌 신청
B. C. Wheeler / 1986 / Current source density estimation using microelectrode array data from the hippocampal slice preparation / IEEE Trans. Biomed. Eng 33 : 1204 ~ 1212
C. A. J. Thomas / 1972 / A miniature microelectrode array to monitor the bioelectric activity of cultured cells / Exp. Cell Res 74 : 61 ~ 66
C. W. Cotman / 1994 / Toward Establi- shing Neural Networks in Culture. in : Enabling Technologies for Cultured Neural Networks / Academic Press : 3 ~ 22
D. A. Borkholder / 1997 / Microelectrode arrays for stimulation of neural slice prepar- ations / J. Neurosci. Methods 77 : 61 ~ 66
D. A. Wagenaar / 2004 / Effective parameters for stimulation of dissociated cultures using multi-electrode arrays / J. Neurosci. Methods 138 : 27 ~ 37
C. A. J. Thomas / 1972 / A miniature microelectrode array to monitor the bioelectric activity of cultured cells / Exp. Cell Res 74 : 61 ~ 66
C. W. Cotman / 1994 / Toward Establi- shing Neural Networks in Culture. in : Enabling Technologies for Cultured Neural Networks / Academic Press : 3 ~ 22
D. A. Borkholder / 1997 / Microelectrode arrays for stimulation of neural slice prepar- ations / J. Neurosci. Methods 77 : 61 ~ 66
D. A. Wagenaar / 2004 / Effective parameters for stimulation of dissociated cultures using multi-electrode arrays / J. Neurosci. Methods 138 : 27 ~ 37
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