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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 303 - 307 (5page)
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Purpose: Caspase-3 is a cysteine protease that plays an important role in the process of apoptotic cell death, but little has been studied clinically on caspase-3 in lung cancer. Increased c-myc expression can result in mitosis or apoptosis, and its contribution to the pathogenesis and prognosis of lung cancer has gained interest. In the present study, the expressions of caspase-3 and c-myc, along with their possible correlations with prognostic variables, were analyzed in resected non-small cell lung carcinomas (NSCLC). Materials and Methods: Archival tumor tissues from 147 previously untreated NSCLC patients were examined by immunohistochemistry for the expressions of caspase-3 and c-myc proteins. Clinical information was obtained through the computerized retrospective database from the tumor registry.Results: The expressions of caspase-3 and c-myc were detected in 60 (88/147) and 16% (24/147) of tumors, respectively. No association was found between caspase-3 and c-myc expressions. A multivariate analysis demonstrated the N status and pathologic stage to be significantly correlated with poor survival (p-value=.018 and .002, respectively), but positive expression of caspase-3 was associated with a good prognosis (p=.03). Conclusion: Our data suggest the involvement of caspase-3 in the tumorigenesis of NSCLC. It is also noteworthy that caspase-3 expression might be a favorable prognostic indicator in these tumors. (Cancer Res Treat. 2004;36:303-307)
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참고문헌 (20)
참고문헌 신청
/ 1990 / c-myc oncoprotein in bronchial carcinoma:expressionin all major morphological types 10 : 623 ~ 628
/ 1993 / The myc family of oncogenesand their presence and importance in small-cell lungcarcinoma and other tumour types 13 : 1373 ~ 1385
/ 1994 / Apoptosis 73 : 2013 ~ 2026
/ 1997 / High levels of expressionand nuclear localization of interleukin-1beta convertingenzyme(ICE)and CPP32 in favorable human neuroblastomas 57 : 4578 ~ 4584
/ 1997 / Immunohistochemical analysis of invivo patterns of expression of CPP32(Caspase-3)a cell deathprotease 57 : 1605 ~ 1613
/ 1993 / The myc family of oncogenesand their presence and importance in small-cell lungcarcinoma and other tumour types 13 : 1373 ~ 1385
/ 1994 / Apoptosis 73 : 2013 ~ 2026
/ 1997 / High levels of expressionand nuclear localization of interleukin-1beta convertingenzyme(ICE)and CPP32 in favorable human neuroblastomas 57 : 4578 ~ 4584
/ 1997 / Immunohistochemical analysis of invivo patterns of expression of CPP32(Caspase-3)a cell deathprotease 57 : 1605 ~ 1613
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