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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 141 - 149 (9page)
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Purpose Reactive oxygen species modulator 1 (Romo1) is a key mediator of intracellular reactive oxygen species production. However, examination of the clinical usefulness of Romo1 in cancers has been limited. We evaluated the association of Romo1 expression with clinical outcomes in advanced non-small cell lung cancer (NSCLC) patients treated with platinumbased chemotherapy.
Materials and Methods Romo1 expression in tumor tissue was examined by immunohistochemistry and evaluated by histological score. Survival analyses were performed according to Romo1 expression and the association between Romo1 expression and clinical parameters was evaluated.
Results A total of 88 tumor specimens were analyzed. Significantly shorter median progression-free survival (PFS) was observed in the high Romo1 group compared with the low Romo1 group (4.5 months vs. 9.8 months, p < 0.001), and the median overall survival (OS) of the high Romo1 group was also significantly shorter than that of the low Romo1 group (8.4 months vs. 15.5 months, p < 0.001). Results of multivariate analyses showed significant association of high Romo1 expression with both poor PFS (hazard ratio [HR], 2.75; 95% confidence interval [CI], 1.71 to 4.44) and poor OS (HR, 3.99; 95% CI, 2.36 to 6.74). Results of the subgroup analysis showed a similar association regardless of tumor histology. Romo1 expression showed no association with any clinical parameter including age, sex, smoking status, stage, differentiation, or tumor histology.
Conclusion Romo1 overexpression was associated with poor response to treatment and shorter survival in advanced NSCLC patients treated with platinum-based chemotherapy. Romo1 could be a potential adverse predictive marker in this setting.
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참고문헌 (25)
참고문헌 신청
Altaha R / 2004 / Excision repair cross complementing-group 1 : gene expression and platinum resistance / Int J Mol Med 14 : 959 ~ 970
Chung JS / 2009 / Mitochondrial reactive oxygen species originating from Romo1 exert an important role in normal cell cycle progression by regulating p27(Kip1)expression / F
Chung JS / 2012 / Overexpression of Romo1 promotes production of reactive oxygen species and invasiveness of hepatic tumor cells / Gastroenterology 143 : 1084 ~ 1094
Chung YM / 2006 / A novel protein, Romo1, induces ROS production in the mitochondria / Biochem Biophys Res Commun 347 : 649 ~ 655
Chung YM / 2008 / Replicative senescence induced by Romo1-derived reactive oxygen species / J Biol Chem 283 : 33763 ~ 33771
Chung JS / 2009 / Mitochondrial reactive oxygen species originating from Romo1 exert an important role in normal cell cycle progression by regulating p27(Kip1)expression / F
Chung JS / 2012 / Overexpression of Romo1 promotes production of reactive oxygen species and invasiveness of hepatic tumor cells / Gastroenterology 143 : 1084 ~ 1094
Chung YM / 2006 / A novel protein, Romo1, induces ROS production in the mitochondria / Biochem Biophys Res Commun 347 : 649 ~ 655
Chung YM / 2008 / Replicative senescence induced by Romo1-derived reactive oxygen species / J Biol Chem 283 : 33763 ~ 33771
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