Anti-HBc 단독 양성자에서 B형 간염 백신 접종의 면역 반응과 B형 간염  DNA의 조사

고희정; 김순덕; 최지호; 김성열; 이진수

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자료유형: 학술저널

저자정보: 고희정 김순덕 최지호 김성열 이진수

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제38권 제2호

발행연도: 2005.1

수록면: 170 - 174 (5page)

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연구주제

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연구배경

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연구방법

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연구결과

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Objectives: The aim of this study was to evaluate the response to a hepatitis B vaccination, and investigate the HBV DNA in subjects with isolated anti-HBc. Methods: 34 subjects with persistent isolated anti-HBc were included in the study. 32 subjects negative for HBsAg, anti-HBs and anti-HBc were included as a control group. They were all vaccinated with Hepaccine at 0, 1 and 2 months, and anti-HBs titers were measured 1 month after the 1st and 3rd vaccinations (1 and 3 months). The HBV-DNA was tested by polymerase chain reaction in subjects with isolated anti-HBc. Results: After the 1st & 3rd vaccinations, the anti-HBs titersက10mIU/ml were 70.6 & 70.6% in isolated anti-HBc group, and 34.4 & 81.2% in the control group, respectively. There were statistically significant differences after the 1st vaccination, but none after the 3rd, between the two groups. In the isolated anti-HBc and control groups, the primary, amnestic and no responses were 0 vs. 46.9%, 55.9 vs. 6.3% and 29.4 vs. 18.8%, respectively. The HBV DNA was not detected in all subjects with isolated anti-HBc. Conclusion: None of the subjects with isolated anti-HBc had a false positive result (primary response); therefore, they should be excluded from vaccination programs in Korea. To differentiate between immunity and occult infections, a single dose of vaccine, with a follow-up anti- HBs test, is preferable for subjects with isolated anti-HBc. An amnestic response indicates late immunity, and no response a suspect occult infection.

#Isolated Anti-HBc #HBV vaccination

참고문헌 (26)

참고문헌 신청

/ 1998 / General recommendations of vaccination Ministry of Health and Welfare AdvisoryCommittee on Vaccination 1998

Andre FE / 1989 / Summary of safety and efficacydata on a yeast-derived hepatitis B vaccine 87

Bart PA / liver1996 / Seroprevalence of HBV and HDV infectionsamong 9006 women at delivery : 110 ~ 116

Chan HY / 1999 / Hepatitis B in adults:Aclinical perspective 3 : 291 ~ 307

Davidson M / 1986 / Recombinant yeasthepatitis B vaccine compared with plasmaderivedvaccine:immunogenicity and effect ofa booster dose 13 : 31 ~ 38

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