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Objectives : A method of estimation using 8 populationbasedcancer registries databases in Korea (KRCR DB)has been introduced as another strategy for validlyestimating the national cancer incidence (NCI) in Korea. The purpose of this study was to evaluate the validity ofthis method with using the 7 KRCR DBs, excluding Seoulcovering 21% of the total population of Korea. Methods : We designed the study method (NCSE_7) assame as the estimating method with using 8 KRCR DBs(NCSE_8) in order to ensure maximal comparability. Wedefined the expected number of cancer cases in eachregistry as the number of observed cases and then weadded the weighted observed cases according to gender,age and the proportion of the population covered by eachregistry for the population of the seven regions and thepopulation of all areas, with excluding these seven regions. From the expected number of total cancer incidents, theestimated NCI was calculated by dividing the expectednumber of cancer cases by the number of the totalpopulation. The standard error (SE) of the estimated incidence was also taken from the expected number of totalcancer incidents. Results : Compared with the results of the NCSE_8, theoverall age-standardized rates (ASR) in men and womenbecame over-estimated and under-estimated, respectively. Primary sites that showed statistically significantdifferences were the colo-rectum, prostate, breast andthyroid. The index of death certificate only (DCO)andmicroscopically verified (MV)% indicating levels of dataquality were decreased, especially for the brain in DCO%and kidney in the MV%. Conclusions : The database of Seoul regional cancerregistry has a key role for the method to estimate the validnationwide cancer statistics in Korea with using thepopulation-based cancer registries databases.

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