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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 527 - 533 (7page)
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초록· 키워드
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Purpose This study was conducted in order to validate the radiosensitization effect of valproic acid, a biologically available histone deacetylase inhibitor, for fractionated radiation.
Materials and Methods Radiosensitization effect of valproic acid was tested for the A549 cell line and U87MG cell line in vitro. Fractionated irradiation of 12 Gy in four fractions was administered on D2-5 with valproic acid, 150 mg/Kg, ip, bid for six consecutive days (D1-6) to A549 and U87MG tumors implanted in BALB/c-nude mice. A growth delay curve was formulated.
Results Radiosensitization effect of valproic acid was found for both cell lines; A549 at 1.5 mM and 3.0 mM concentration and U87MG at 3.0 mM concentration. In growth delay analysis, a statistically significant radiosensitization effect was observed for both tumors (p < 0.001 for both tumors). Difference for change in slope for control and valproic acid versus radiotherapy and radiotherapy plus valproic acid showed borderline significance for the U87MG cell line (p=0.065), indicating beyond additive effect, whereas this difference was statistically insignificant for A549 tumor (p=0.951), indicating additive effect.
Conclusion Results of this study indicate that a radiosensitizing effect for fractionated radiotherapy of valproic acid for A549 and U87MG tumors in vivo is evident and that it may be more than additive for U87MG tumors. Further exploitation of histone deacetylase inhibitors in clinical trials is warranted.
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참고문헌 (24)
참고문헌 신청
Baylin SB / 2006 / Epigenetic gene silencing in cancer: a mechanism for early oncogenic pathway addiction? / Nat Rev Cancer 6 : 107 ~ 116
Camphausen K / 2005 / Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid / Int J Cancer 114 : 380 ~ 386
Camphausen K / 2007 / Inhibition of histone deacetylation : a strategy for tumor radiosensitization / J Clin Oncol 25 : 4051 ~ 4056
Chang AR / 2007 / Histone deacetylase inhibitory activity of valproic acid in glioblastoma / J Korean Soc Ther Radiol Oncol 25 : s30 ~
Chen X / 2009 / HDAC inhibitor, valproic acid, induces p53-dependent radiosensitization of colon cancer cells / Cancer Biother Radiopharm 24 : 689 ~ 699
Camphausen K / 2005 / Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid / Int J Cancer 114 : 380 ~ 386
Camphausen K / 2007 / Inhibition of histone deacetylation : a strategy for tumor radiosensitization / J Clin Oncol 25 : 4051 ~ 4056
Chang AR / 2007 / Histone deacetylase inhibitory activity of valproic acid in glioblastoma / J Korean Soc Ther Radiol Oncol 25 : s30 ~
Chen X / 2009 / HDAC inhibitor, valproic acid, induces p53-dependent radiosensitization of colon cancer cells / Cancer Biother Radiopharm 24 : 689 ~ 699
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